Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The over-expression of somatostatin in the gerbil entorhinal cortex induced by seizure
Autore:
Kang, TC; Park, SK; Do, SG; Suh, JG; Jo, SM; Oh, YS; Jeong, YG; Won, MH;
Indirizzi:
Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, Kangwon Do, South KoreaHallym Univ Chunchon Kangwon Do South Korea 200702 angwon Do, South Korea Hallym Univ, Coll Med, Expt Anim Ctr, Chunchon 200702, Kangwon Do, South Korea Hallym Univ Chunchon Kangwon Do South Korea 200702 angwon Do, South Korea Konyang Univ, Coll Med, Dept Anat, Nonsan 320711, South Korea Konyang Univ Nonsan South Korea 320711 Anat, Nonsan 320711, South Korea
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 882, anno: 2000,
pagine: 55 - 61
SICI:
0006-8993(20001103)882:1-2<55:TOOSIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; MESSENGER-RNA EXPRESSION; NEUROPEPTIDE-Y; MONGOLIAN GERBIL; RAT HIPPOCAMPUS; IMMUNOREACTIVE NEURONS; SELECTIVE LOSS; DENTATE GYRUS; RELEASE;
Keywords:
somatostatin; hippocampus; dentate hilus; subiculum; mongolian gerbil; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Won, MH Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, Kangwon Do, South Korea Hallym Univ Chunchon Kangwon Do South Korea 200702 o, South Korea
Citazione:
T.C. Kang et al., "The over-expression of somatostatin in the gerbil entorhinal cortex induced by seizure", BRAIN RES, 882(1-2), 2000, pp. 55-61

Abstract

In present study, we investigated the immunohistochemical distribution of somatostatin (SRIF) in the hippocampal complex of the Mongolian gerbil and its association with different sequelae of spontaneous seizures, in an effort to identify the roles of SRIF in the self-recovery mechanisms in these animals. In the dentate gyrus and subiculum, SRIF immunoreactive (SRIF+) cells were similar in both the seizure resistant and the pre-seizure group of seizure sensitive gerbils. Interestingly, SRIF immunoreactivity was markedly decreased until 12 h postictal. Twenty-four hours after the on-set of seizure, the distribution of SRIF immunoreactivity in these regions had slightly increased. In contrast, in the entorhinal cortex the population of SRIFcells and their density were significantly elevated compared to pre-seizure group 30 min postictal. Twelve hours after the on-set of seizure, however, the population of SRIF+ cells and their density declined, approximately 70-80% compared to the situation at 30 min postictal. These findings suggestthat the enhancement of SRIF expression in gerbil entorhinal cortex may affect tissue excitability and have a role in modulating recurrent excitationfollowing seizures. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:23:35