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Titolo:
Age-related reduction of [C-11]MDL100,907 binding to central 5-HT2A receptors: PET study in the conscious monkey brain
Autore:
Kakiuchi, T; Nishiyama, S; Sato, K; Ohba, H; Nakanishi, S; Tsukada, H;
Indirizzi:
Hamamatsu Photon KK, Cent Res Lab, Shizuoka 4348601, Japan Hamamatsu Photon KK Shizuoka Japan 4348601 Lab, Shizuoka 4348601, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 883, anno: 2000,
pagine: 135 - 142
SICI:
0006-8993(20001110)883:1<135:ARO[BT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 ALTANSERIN; IN-VIVO; AUTORADIOGRAPHIC ANALYSIS; ALZHEIMERS-DISEASE; CEREBRAL-CORTEX; RAT-BRAIN; SEROTONIN; SITES; INCREASES;
Keywords:
serotonin receptor; [C-11]MDL100,907; aging; monkey brain; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, H Hamamatsu Photon KK, Cent Res Lab, 5000 Hirakuchi, Shizuoka 4348601, Japan Hamamatsu Photon KK 5000 Hirakuchi Shizuoka Japan 4348601 apan
Citazione:
T. Kakiuchi et al., "Age-related reduction of [C-11]MDL100,907 binding to central 5-HT2A receptors: PET study in the conscious monkey brain", BRAIN RES, 883(1), 2000, pp. 135-142

Abstract

Age-related alterations of serotonin (5-hydroxytryptamine; 5-HT) type 2A receptors (5-HT2A) in the living brains of young (6.0+/-1.3 years old) and aged (19.2+/-3.0 years old) monkeys (Macaca mulatta) were evaluated with [C-11]MDL100,907 in the conscious state using high-resolution positron emission tomography (PET). For quantitative analysis of 5-HT2A binding in vivo, PET scan of [C-11]MDL100,907 was performed with arterial blood sampling in each animal, and the metabolic-corrected arterial input function was used forLogan graphical analysis. Higher cerebral binding of [C-11]MDL100,907 was observed in the hippocampus, cingulate gyrus, frontal, temporal and occipital cortices, regions known to contain high densities of 5-HT2A, by in vitroassay. Binding was intermediate in the striatum and thalamus, and lower inthe pens and cerebellum in both young and aged monkeys. The age-related decrease in [C-11]MDL100,907 binding to 5-HT2A receptors was prominent in thehippocampus, cingulate gyrus, frontal, temporal and occipital cortices, but not in the striatum, thalamus and pens. These observation demonstrated the usefulness of [C-11]MDL100,907 as an labeled compound for assessment of the aging process of the cortical 5-HT2A measured by PET. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:02:59