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Titolo:
Effects of alendronate on osteopenic postmenopausal Chinese women
Autore:
Yen, ML; Yen, BL; Jang, MH; Hsu, SHJ; Cheng, WC; Tsai, KS;
Indirizzi:
Natl Taiwan Univ, Coll Med, Dept Obstet & Gynecol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 tet & Gynecol, Taipei 10018, Taiwan Natl Taiwan Univ, Coll Med, Dept Lab Med, Taipei 10018, Taiwan Natl TaiwanUniv Taipei Taiwan 10018 Dept Lab Med, Taipei 10018, Taiwan Taipei City Psychiat Ctr, Taipei, Taiwan Taipei City Psychiat Ctr TaipeiTaiwan ity Psychiat Ctr, Taipei, Taiwan
Titolo Testata:
BONE
fascicolo: 5, volume: 27, anno: 2000,
pagine: 681 - 685
SICI:
8756-3282(200011)27:5<681:EOAOOP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING BISPHOSPHONATES INHIBIT; FRACTURE INTERVENTION TRIAL; BONE-RESORPTION; ORAL ALENDRONATE; VERTEBRAL FRACTURES; ELDERLY WOMEN; HIP-FRACTURES; OSTEOPOROSIS; DENSITY; MARKERS;
Keywords:
bone mineral density (BMD); spine; hip; N-telopeptide of type I collagen (NTx); deoxypyridinoline (Dpd);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, KS Natl Taiwan Univ Hosp, Dept Lab Med, 7 Chung Shan S Rd, Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 Taiwan
Citazione:
M.L. Yen et al., "Effects of alendronate on osteopenic postmenopausal Chinese women", BONE, 27(5), 2000, pp. 681-685

Abstract

To evaluate the effects of alendronate on postmenopausal Chinese women with osteopenia, we treated 46 subjects daily with either 10 mg alendronate (N= 24) or placebo plus 500 mg calcium supplement (N = 22), and measured their bone mineral density (BMD) at the lumbar spine and hip, and urinary boneresorption markers before, during, and after the 1 year treatment period. The bone markers included N-telopeptide of type I collagen (NTx) and deoxypyridinoline (Dpd); both were corrected by the concentration of creatinine in the same sample (NTx/Cr and Dpd/Cr), Both NTx/Cr and Dpd/Cr decreased significantly by 44% and 28%, respectively (p < 0.05 for both), in 1 month in the active treatment group but did not change in the placebo group. BMD at the spine, femoral neck, trochanter, and Ward's triangle increased significantly by 6 months and showed a further increase through month 12 at the spine in the alendronate-treated group, Relative to the placebo group, BMD changes at various sites in the alendronate-treated group were higher at 12 months by 6%-11%, Thus, our data suggest that 10 mg alendronate daily resulted in significant increases in spine and hip BMD, and decreases of urinary resorption markers in the osteopenic postmenopausal Chinese women studied. The amplitude of responses was higher than in previous reports in the USA and Europe. (C) 2000 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:37:52