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Titolo:
Molecular mechanisms of platelet exocytosis: insights into the "secrete" life of thrombocytes
Autore:
Reed, GL; Fitzgerald, ML; Polgar, J;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Cardiovasc Biol Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ardiovasc Biol Lab, Boston, MA 02115 USA Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Cardiol, Boston, MA 02114 USA
Titolo Testata:
BLOOD
fascicolo: 10, volume: 96, anno: 2000,
pagine: 3334 - 3342
SICI:
0006-4971(20001115)96:10<3334:MMOPEI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEDIAK-HIGASHI-SYNDROME; STORAGE POOL DEFICIENCY; HERMANSKY-PUDLAK-SYNDROME; PROTEIN-KINASE-C; PERMEABILIZED HUMAN-PLATELETS; ALPHA-GRANULE MEMBRANE; GLYCOPROTEIN-IIB-IIIA; HUMAN BLOOD-PLATELETS; ADRENAL CHROMAFFIN CELLS; GUINEA-PIG MEGAKARYOCYTE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
176
Recensione:
Indirizzi per estratti:
Indirizzo: Reed, GL Harvard Univ, Sch Publ Hlth, Cardiovasc Biol Lab, 11-127,677 Huntington Ave, Boston, MA 02115 USA Harvard Univ 11-127,677 Huntington Ave Boston MA USA 02115 15 USA
Citazione:
G.L. Reed et al., "Molecular mechanisms of platelet exocytosis: insights into the "secrete" life of thrombocytes", BLOOD, 96(10), 2000, pp. 3334-3342

Abstract

The critical role played by platelets in hemostasis, thrombosis, vascular remodeling, and healing is related to their function as exocytotic cells that secrete important effector molecules al:the site of vascular injury. Recent insights into molecular mechanisms of secretion indicate that platelet granule secretion is homologous to exocytosis in neurons and other cells but involves a platelet-selective machinery that is uniquely coupled to cell activation. This review summarizes these recent insights in the context of the burgeoning literature on mechanisms of exocytosis in neurons and other cells-illustrating the fundamental homologies and the unique characteristics of platelet secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 10:00:35