Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Progestin effects on long-term growth, death, and bcl-xL in breast cancer cells
Autore:
Moore, MR; Conover, JL; Franks, KM;
Indirizzi:
Marshall Univ, Sch Med, Dept Biochem & Mol Biol, Huntington, WV 25704 USA Marshall Univ Huntington WV USA 25704 Mol Biol, Huntington, WV 25704 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 277, anno: 2000,
pagine: 650 - 654
SICI:
0006-291X(20001102)277:3<650:PEOLGD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-TALK; LINE T47D; TAMOXIFEN; ESTROGEN; RECEPTOR; KINASE; CARCINOGENESIS; STIMULATION; EXPRESSION; PATHWAYS;
Keywords:
progestins; breast cancer; growth; cell death; bcl-xL; bcl-2; bax; T47D cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, MR Marshall Univ, Sch Med, Dept Biochem & Mol Biol, Huntington, WV 25704 USA Marshall Univ Huntington WV USA 25704 Huntington, WV 25704 USA
Citazione:
M.R. Moore et al., "Progestin effects on long-term growth, death, and bcl-xL in breast cancer cells", BIOC BIOP R, 277(3), 2000, pp. 650-654

Abstract

The effect of progestins on proliferation of breast cancer has been a controversial area. We have consistently reported progestin stimulation of proliferation in the progesterone receptor-rich human breast cancer cell line T47D. Other authors, under other conditions, have agreed that progestins stimulate, but for just one turn of the cell cycle. To our knowledge, this is the first in vitro report to show progestin stimulation of human breast cancer cell growth for multiple, probably unlimited, cell cycles, while control cells are dying. This is accompanied by progestin up-regulation of the antiapoptotic protein bcl-xL, no effect on the pro-apoptotic protein bar, and, surprisingly, diminution of the antiapoptotic protein bcl-2. Thus, progestins both serve as survival factors and stimulate proliferation, implying apossible similar role in breast cancer patients. The data support the notion that many patients may benefit more from combined antiprogestin-antiestrogen therapy than from antiestrogen alone, and suggest bcl-x(L) as a possible target for breast cancer therapy. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:14:22