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Titolo:
Dietary salt and urinary calcium excretion in a human bed rest spaceflightmodel
Autore:
Arnaud, SB; Wolinsky, I; Fung, P; Vernikos, J;
Indirizzi:
NASA, Ames Res Ctr, Div Life Sci, Moffett Field, CA 94035 USA NASA Moffett Field CA USA 94035 Div Life Sci, Moffett Field, CA 94035 USA Univ Houston, Dept Human Dev, Houston, TX USA Univ Houston Houston TX USA niv Houston, Dept Human Dev, Houston, TX USA
Titolo Testata:
AVIATION SPACE AND ENVIRONMENTAL MEDICINE
fascicolo: 11, volume: 71, anno: 2000,
pagine: 1115 - 1119
SICI:
0095-6562(200011)71:11<1115:DSAUCE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTION; TRANSPORT; SODIUM; RAT;
Keywords:
dietary salt; urinary calcium excretion; urinary cAMP; parathyroid hormone; bed rest;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Arnaud, SB NASA, Ames Res Ctr, Div Life Sci, SL 239-11, Moffett Field, CA 94035 USA NASA SL 239-11 Moffett Field CA USA 94035 t Field, CA 94035 USA
Citazione:
S.B. Arnaud et al., "Dietary salt and urinary calcium excretion in a human bed rest spaceflightmodel", AVIAT SP EN, 71(11), 2000, pp. 1115-1119

Abstract

Background: Dietary salt is known to increase the excretion of urinary calcium (Ca). To determine the potential role of dietary sodium (Na) on the calciuria associated with a spaceflight simulation model, we evaluated urinary Ca in two groups of bed rest subjects fed either high or low normal amounts of salt. Methods: We analyzed urinary Ca excretion expressed in terms ofcreatinine (UCa/Cr), fractional Ca excretion (FECa), and urinary cAMP (UCAMP) as an index of parathyroid function, in the urine of 30-50-yr-old male volunteers for 6 degrees head down tilt bed rest studies. Dietary Na was inthe high normal range (190 mmol.d(-1)) in 8 men for 7 d (HiNa), and in thelow normal range (114 mmol.d(-1)) in 11 men for 30 d (LoNa) bed rest. Dietary Ca averaged 20 mmol.d(-1) in both studies. Results: Within the first 3 bed rest days, subjects in the HiNa study showed increases in UCa/Cr (0.1130 +/- 0.05 to 0.161 +/- 0.05, p < 0.002) and in FECa (1.95 <plus/minus> 0.70 to 3.19 +/-. 0.93, p < 0.001); those in LoNa showed no change in UCa/Cr (0.125 <plus/minus> 0.06 to 0.121 +/- 0.07, NS) or FECa (1.93 +/- 0.75 to 2.22 +/- 0.63). After the 5th bed rest day UCa/Cr stabilized at similar levels in both dietary groups. UCAMP decreased 20% during the first week of bed rest with HiNa, but not until the third week with LoNa diets (p < 0.05). Conclusion: These findings implicate high salt diets in Ca excretion in a spaceflight model and suggest that low normal salt diets may reduce early calciuria associated With spaceflight.

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Documento generato il 04/12/20 alle ore 16:36:07