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Titolo:
Maternal effect on Parkinson's disease
Autore:
de la Fuente-Fernandez, R;
Indirizzi:
Hop A Marcide, Div Neurol, La Coruna, Spain Hop A Marcide La Coruna Spain p A Marcide, Div Neurol, La Coruna, Spain
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 48, anno: 2000,
pagine: 782 - 787
SICI:
0364-5134(200011)48:5<782:MEOPD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-SYNUCLEIN GENE; COMPLEX-I DEFICIENCY; RISK-FACTORS; TWINS; INHERITANCE; MUTATION; TRANSMISSION; FAMILIES; DEFECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: de la Fuente-Fernandez, R Univ British Columbia, Vancouver Hosp & Hlth SciCtr, Ctr Neurodegenerat Disorders, Purdy Pavil,2221 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada Univ British Columbia Purdy Pavil,2221 Wesbrook MallVancouver BC Canada V6T 2B5
Citazione:
R. de la Fuente-Fernandez, "Maternal effect on Parkinson's disease", ANN NEUROL, 48(5), 2000, pp. 782-787

Abstract

First-degree relatives of patients with Parkinson's disease (PD) are at higher risk for PD development than first-degree relatives of control subjects, but clinical twin studies have failed to demonstrate a genetic basis in PD. It is hypothesized that maternal exposure to certain environmental factors could lead to pathological changes in the ovum that predispose to the development of PD in the child. In this study of 299 patients and 295 controls, the age at onset of PD was found to correlate negatively with maternal age at birth of patient but not with paternal age. Mothers and fathers of patients with PD had an increased risk of PD as compared with parents of control subjects. These results suggest a maternal effect on PD that could be primarily environmental in nature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:23:05