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Titolo:
Neuromuscular monitoring at the orbicularis oculi may overestimate the blockade in myasthenic patients
Autore:
Itoh, H; Shibata, K; Yoshida, M; Yamamoto, K;
Indirizzi:
Kanazawa Univ, Fac Med, Dept Anesthesia & Intens Care Med, Kanazawa, Ishikawa, Japan Kanazawa Univ Kanazawa Ishikawa Japan are Med, Kanazawa, Ishikawa, Japan
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 5, volume: 93, anno: 2000,
pagine: 1194 - 1197
SICI:
0003-3022(200011)93:5<1194:NMATOO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR POLLICIS MUSCLES; ACETYLCHOLINE-RECEPTOR; VECURONIUM; GRAVIS; SENSITIVITY; MIVACURIUM;
Keywords:
acceleration; myasthenia gravis; nondepolarizing neuromuscular blocker; Osserman classification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Itoh, H Kanazawa Univ, Fac Med, Dept Anesthesia & Intens Care Med, 13-1 Takara Machi, Kanazawa, Ishikawa, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan wa, Japan
Citazione:
H. Itoh et al., "Neuromuscular monitoring at the orbicularis oculi may overestimate the blockade in myasthenic patients", ANESTHESIOL, 93(5), 2000, pp. 1194-1197

Abstract

Background: In most publications about myasthenia, monitoring neuromuscular blockade during anesthesia is recommended. In healthy patients, the relation of blockade between muscles has been established, but there is little information about the relation in myasthenic patients. Our objective was to investigate whether the relation between the orbicularis oculi and adductorpollicis muscles is the same in healthy patients and myasthenic patients. Methods: After anesthesia was induced with 4-6 mg/kg thiopental and 2 mug/kg fentanyl, followed by 2% sevoflurane and 60% nitrous oxide in oxygen, 10healthy patients and 10 myasthenic patients received 0.025 and 0.01 mg/kg vecuronium, respectively. Neuromuscular monitoring was performed with use of accelerometry at the orbicularis oculi and the adductor pollicis muscles by stimulating the temporal branch of the facial nerve and the ulnar nerve. Results: The relation of blockade between these two muscles was not the same in healthy patients and myasthenic patients: in healthy patients, the maximum neuromuscular blockade with 0.025 mg/kg vecuronium was less in the orbicularis oculi than in the adductor pollicis (median 72% vs. 91%; P < 0.05); in contrast, in myasthenic patients, the blockade with 0.01 mg/kg vecuronium was greater in the orbicularis oculi than in the adductor pollicis (median 96% vs, 62%; P < 0.05). Conclusion: Neuromuscular monitoring at the orbicularis oculi may overestimate blockade in myasthenic patients. Extubation must be performed when themuscle most sensitive to neuromuscular blocking agents Is recovered. Therefore, neuromuscular monitoring at the orbicularis oculi is recommended to avoid persistent neuromuscular blockade in patients with myasthenia gravis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:19:06