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Titolo:
Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects
Autore:
Festa, A; DAgostino, R; Rautaharju, P; Mykkanen, L; Haffner, SM;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 Epidemiol, San Antonio, TX 78284 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA bl Hlth Sci, Winston Salem, NC USA Wake Forest Univ, Bowman Gray Sch Med, EPICARE Ctr, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA EPICARE Ctr, Winston Salem, NC USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 10, volume: 86, anno: 2000,
pagine: 1117 - 1122
SICI:
0002-9149(20001115)86:10<1117:ROSBPL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TOLERANCE TEST; CARDIOVASCULAR MORTALITY; MINIMAL MODEL; OLDER ADULTS; POPULATION; HEART; COMPLICATIONS; PROLONGATION; EXPERIENCE; ADIPOSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Haffner, SM Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 284 USA
Citazione:
A. Festa et al., "Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects", AM J CARD, 86(10), 2000, pp. 1117-1122

Abstract

A prolonged QT interval has been identified as a risk factor for cardiovascular disease; however, knowledge about etiologic factors is limited. We studied determinants of QT interval duration in the Insulin Resistance Atherosclerosis Study, a large, triethnic population (n = 1,577) with varying degrees of glucose tolerance. In particular, we sought to investigate the relatian of QT interval with blood pressure (BP), left ventricular (LV) mass, estimated using electrocardiographic criteria, and insulin sensitivity, directly measured by a frequently sampled intravenous glucose tolerance test. QT interval was measured electronically on electrocardiograms at rest and corrected for heart rate using standard equations, The QT interval was related to various components of the insulin resistance syndrome, including BP and insulin sensitivity. Multivariate analyses showed that BP and LV mass were the main determinants of the QT interval in diabetic and nondiabetic subjects. Additionally, prevalent coronary artery disease was related to the QTinterval in subjects with newly diagnosed diabetes. In conclusion, we found that BP and LV mass were the strongest and most consistent determinants of the QT interval in nondiabetic and diabetic subjects. Additional factors potentially contributing to QT interval prolongation in diabetic patients include insulin sensitivity and prevalent coronary artery disease. (C) 2000 by Excerpta Medico, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:46:26