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Titolo:
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy - A retrospective study of 19 cases
Autore:
Berkane, N; Cocheton, JJ; Brehier, D; Merviel, P; Wolf, C; Lefevre, G; Uzan, S;
Indirizzi:
Hop Tenon, Serv Gynecol Obstet & Med Reprod, F-75020 Paris, France Hop Tenon Paris France F-75020 bstet & Med Reprod, F-75020 Paris, France Hop Tenon, Serv Med Interne, F-75020 Paris, France Hop Tenon Paris France F-75020 , Serv Med Interne, F-75020 Paris, France Hop St Antoine, Serv Biochim, Paris, France Hop St Antoine Paris FranceHop St Antoine, Serv Biochim, Paris, France Hop Tenon, Serv Biochim, AP HP, F-75970 Paris, France Hop Tenon Paris France F-75970 erv Biochim, AP HP, F-75970 Paris, France
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 11, volume: 79, anno: 2000,
pagine: 941 - 946
SICI:
0001-6349(200011)79:11<941:UAIICO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-HEPATIC CHOLESTASIS; OBSTETRIC CHOLESTASIS; MANAGEMENT; PATHOGENESIS; THERAPY; LIVER; WOMEN;
Keywords:
cholestasis; maternal and fetal outcome; pregnancy; treatment; ursodeoxycholic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Berkane, N Hop Tenon, Serv Gynecol Obstet & Med Reprod, 4 Rue Chine, F-75020 Paris, France Hop Tenon 4 Rue Chine Paris France F-75020 75020 Paris, France
Citazione:
N. Berkane et al., "Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy - A retrospective study of 19 cases", ACT OBST SC, 79(11), 2000, pp. 941-946

Abstract

Objective. We studied the clinical and biological effects and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy (TCP). Methods. All cases of ICP treated with ursodeoxycholic acid in our department from January Ist, 1991 to May 31st, 1997 were reviewed. Results. Forty-three patients had ICP, of whom 19 received ursodeoxycholicacid. The first symptoms appeared after a mean of 29.7 weeks of pregnancy (WP). Treatment was started after a mean of 32 WP, and lasted a mean of 28.5 days. Fourteen patients showed a clinical improvement on UDCA, and 11 showed a biological improvement. Two had a biological deterioration with increased liver enzyme concentrations. Conclusions. Ursodeoxycholic acid appears to be an effective treatment forICP, but further studies are needed to confirm its safety in pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:28:05