Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
Autore:
Giasson, BI; Duda, JE; Murray, IVJ; Chen, QP; Souza, JM; Hurtig, HI; Ischiropoulos, H; Trojanowski, JQ; Lee, VMY;
Indirizzi:
Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Dis Res, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia, Dept Biochem & Biophys, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Stokes Res Inst, Philadelphia, PA 19104 USA Stokes Res Inst Philadelphia PA USA 19104 nst, Philadelphia, PA 19104 USA
Titolo Testata:
SCIENCE
fascicolo: 5493, volume: 290, anno: 2000,
pagine: 985 - 989
SICI:
0036-8075(20001103)290:5493<985:ODLTNB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SYSTEM ATROPHY; PARKINSONS-DISEASE; LEWY BODIES; ALZHEIMERS-DISEASE; NITRIC-OXIDE; TYROSINE NITRATION; PEROXYNITRITE; DEMENTIA; INCLUSIONS; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Giasson, BI Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 hiladelphia, PA 19104 USA
Citazione:
B.I. Giasson et al., "Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions", SCIENCE, 290(5493), 2000, pp. 985-989

Abstract

Aggregated alpha -synuclein proteins form brain Lesions that are hallmarksof neurodegenerative synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of these disorders. Using antibodies to specific nitrated tyrosine residues in alpha -synuclein, we demonstrate extensive and widespread accumulations of nitrated alpha -synuclein in the signature inclusions of Parkinson's disease, dementia with Lewy bodies, the Lewy body variant of Alzheimer's disease, and multiple system atrophy brains. We also show that nitrated alpha -synuclein is present in the major filamentous building blocks of these inclusions, as well as in the insoluble fractions of affected brain regions of synucleinopathies. The selective and specific nitration of alpha -synuclein in these disorders provides evidence todirectly link oxidative and nitrative damage to the onset and progression of neurodegenerative synucleinopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:43:48