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Titolo:
POLYMORPHISMS IN THE APOLIPOPROTEIN(A) GENE AND THEIR RELATIONSHIP TOALLELE SIZE AND PLASMA LIPOPROTEIN(A) CONCENTRATION
Autore:
PUCKEY LH; LAWN RM; KNIGHT BL;
Indirizzi:
HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,CTR CLIN SCI,MRC LIPOPROT TEAM LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,CTR CLIN SCI,MRC LIPOPROT TEAM LONDON W12 0NN ENGLAND STANFORD UNIV,SCH MED,DIV CARDIOVASC MED STANFORD CA 94305
Titolo Testata:
Human molecular genetics
fascicolo: 7, volume: 6, anno: 1997,
pagine: 1099 - 1107
SICI:
0964-6906(1997)6:7<1099:PITAGA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE DISEQUILIBRIUM; FAMILIAL HYPERCHOLESTEROLEMIA; SEQUENCE POLYMORPHISMS; MESSENGER-RNA; APO(A) GENE; PLASMINOGEN; LP(A); REGION; LOCUS; GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L.H. Puckey et al., "POLYMORPHISMS IN THE APOLIPOPROTEIN(A) GENE AND THEIR RELATIONSHIP TOALLELE SIZE AND PLASMA LIPOPROTEIN(A) CONCENTRATION", Human molecular genetics, 6(7), 1997, pp. 1099-1107

Abstract

Genotypes at five previously described polymorphic sites at the apolipoprotein(a) gene locus have been determined for the members of 27 families as well as for unrelated white Caucasian and Asian-Indian subjects, and their relationship with isoform size and plasma lipoprotein(a)concentrations investigated, There was strong linkage disequilibrium between sites at the 5'-region of the gene and also between this region and a site in the coding sequence for Kringle 4-37 on the other sideof the polymorphic Kringle 4 repeat region, There was no evidence that changes at any of the sites had any direct effect upon lipoprotein(a) concentration. However, certain haplotypes were present almost exclusively on apolipoprotein(a) alleles within a restricted range of sizesand associated lipoprotein(a) concentrations. After correcting for the effect of allele size, there were clear differences between the lipoprotein(a) concentrations associated with alleles of different haplotypes, suggesting that there may be genetically distinct groups of apolipoprotein alleles of different size and different levels of expression, Factors that regulate expression apparently exchange at a rate similar to the rate of change of Kringle 4 repeat number.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:18:54