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Titolo:
Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia
Autore:
Krebs, MO; Gut-Fayand, A; Bourdel, MC; Dischamp, J; Olie, JP;
Indirizzi:
Univ Paris 05, Ctr Hosp St Anne, Serv Hosp Univ Sante Mentale & Therapeut,Lab Psychiat Biol, Paris, France Univ Paris 05 Paris France & Therapeut,Lab Psychiat Biol, Paris, France
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 45, anno: 2000,
pagine: 245 - 260
SICI:
0920-9964(20001027)45:3<245:VAFSOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMALITIES; DYSFUNCTION; INSTRUMENT; INVENTORY; DISORDERS; SCALE;
Keywords:
factorial structure; integrative function; mood disorder; motor coordination; neuroleptic; neurological soft signs; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Krebs, MO Univ Paris 05, Ctr Hosp St Anne, Serv Hosp Univ Sante Mentale & Therapeut,Lab Psychiat Biol, Paris, France Univ Paris 05 Paris France t,Lab Psychiat Biol, Paris, France
Citazione:
M.O. Krebs et al., "Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia", SCHIZOPHR R, 45(3), 2000, pp. 245-260

Abstract

Although neurological soft signs (NSS) have been consistently reported in patients with schizophrenia, their clinical relevance, the actual impact oftreatment or their evolution during the disease are not well clarified, possibly because of methodological limitations of the available tools. We have developed a new standardized examination integrating the assessment of 23NSS selected from the literature and the rating of well-validated scales for assessment of extra-pyramidal symptoms. We examined 161 subjects (controls, n=48; patients with schizophrenia, n=95; or recurrent mood disorder, n=18). Half of the patients were neuroleptic-free. Schizophrenic patients hadsignificantly higher total score (14.6+/-8) than mood disorder patients (12.0+/-7) and controls (5.0+/-2). Internal consistency (Cronbach's alpha=0.85) and inter-rater reliability were good. Principal component analysis found five consistent factors ('motor coordination', 'motor integrative function','sensory integration', 'involuntary movements or posture', 'quality of lateralization'). This scale thus confirmed a factorial structure in agreement with the conceptual areas of interest explored by NSS and should be a useful tool for assessment of the different dimensions of neurological dysfunction in schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:26:42