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Titolo:
Gonadal and adrenal sex steroids in ankylosing spondylitis
Autore:
Gooren, LJG; Giltay, EJ; van Schaardenburg, D; Dijkmans, BAC;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Endocrinol, Div Androl, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Res Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands
Titolo Testata:
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
fascicolo: 4, volume: 26, anno: 2000,
pagine: 969 -
SICI:
0889-857X(200011)26:4<969:GAASSI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; SERUM TESTOSTERONE LEVELS; MIDDLE-AGED MEN; RHEUMATOID-ARTHRITIS; T-CELLS; BIOCHEMICAL MARKERS; ANDROGEN RECEPTORS; HORMONE LEVELS; WOMEN; HLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Gooren, LJG Free Univ Amsterdam Hosp, Dept Endocrinol, Div Androl, POB7057, NL-1007 MBAmsterdam, Netherlands Free Univ Amsterdam Hosp POB7057 Amsterdam Netherlands NL-1007 MB
Citazione:
L.J.G. Gooren et al., "Gonadal and adrenal sex steroids in ankylosing spondylitis", RHEUM DIS C, 26(4), 2000, pp. 969

Abstract

The frequency and severity of ankylosing spondylitis (AS) shows a male preponderance. In search of an explanation, some authors have reported that serum androgen relative to estrogen levels are slightly elevated in AS patients compared to controls. However, more recent, better designed studies havefound the serum testosterone, 17B-estradiol and androstenedione levels didnot differ significantly between patients with AS and controls. The sex difference in AS prevalence remains intriguing and there may be a role for (normal male levels) androgens exerting an effect on immune processes involved in the pathogenesis of AS.

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Documento generato il 02/12/20 alle ore 17:53:33