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Titolo:
Effects of hemoglobin on pulmonary arterial pressure and pulmonary vascular resistance in patients with chronic emphysema
Autore:
Nakamura, A; Kasamatsu, N; Hashizume, I; Shirai, T; Hanzawa, S; Momiki, S; Sasaki, K; Kinoshita, M; Okada, O; Tatsumi, K; Kuriyama, T;
Indirizzi:
Chiba Univ, Dept Chest Med, Chiba, Japan Chiba Univ Chiba JapanChiba Univ, Dept Chest Med, Chiba, Japan Hamamatsu Med Ctr, Dept Resp Med, Hamamatsu, Shizuoka, Japan Hamamatsu MedCtr Hamamatsu Shizuoka Japan d, Hamamatsu, Shizuoka, Japan Hamamatsu Med Ctr, Dept Thorac Surg, Hamamatsu, Shizuoka, Japan Hamamatsu Med Ctr Hamamatsu Shizuoka Japan g, Hamamatsu, Shizuoka, Japan
Titolo Testata:
RESPIRATION
fascicolo: 5, volume: 67, anno: 2000,
pagine: 502 - 506
SICI:
0025-7931(200009/10)67:5<502:EOHOPA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC COR-PULMONALE; HYPERTENSION; POLYCYTHEMIA; RATS;
Keywords:
chronic emphysema; hemoglobin level; pulmonary arterial pressure; pulmonary vascular resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, A Chiba Univ, Sch Med, Dept Physiol 2, Chuo Ku, 1-8-1 Inohana, Chiba 2600856, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2600856 a 2600856, Japan
Citazione:
A. Nakamura et al., "Effects of hemoglobin on pulmonary arterial pressure and pulmonary vascular resistance in patients with chronic emphysema", RESPIRATION, 67(5), 2000, pp. 502-506

Abstract

Background: The increase in viscosity caused by secondary polycythemia is thought to be one of the major causes of pulmonary hypertension secondary to chronic emphysema. However, very few clinical studies considered the relation between pulmonary hypertension and polycythemia in the case of chronicobstructive pulmonary disease. Objective: The purpose of this study is to elucidate the relative contribution of an increase in hemoglobin level (Hb)to mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). Methods: We retrospectively investigated 41 patients with chronic emphysema who had undergone a right heart catheterization. Multiple-regression analysis and F test were performed to investigate both direct effects of Hb and PaO2 as independent variables on mPAP and PVR as dependent variables. Results: Significant correlations were found between PaO2 and mPAP (or PVR), or Hb and mPAP (or PVR), indicating that both Hb and PaO2 are contributory to mPAP and PVR. The F test demonstrated that Hb and PaO2 could directly affect the level of either mPAP or PVR, Conclusions: It was concluded that Hb had a direct effect on mPAP and PVR, independently of hypoxia in patients with chronic emphysema, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 16:00:07