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Titolo:
IDENTIFICATION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN SENILE PLAQUES AND REACTIVE MICROGLIA OF ALZHEIMERS-DISEASE
Autore:
ISHIZUKA K; KIMURA T; IGATAYI R; KATSURAGI S; TAKAMATSU J; MIYAKAWA T;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DEPT NEUROPSYCHIAT,HONJO 1-1-1 KUMAMOTO 860 JAPAN NATL KIKUCHI HOSP KUMAMOTO JAPAN
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 51, anno: 1997,
pagine: 135 - 138
SICI:
1323-1316(1997)51:3<135:IOMCPI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-AMYLOID PROTEIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ASTROCYTE EXPRESSION; PRECURSOR PROTEIN; PEPTIDE; BRAIN; ENCEPHALOMYELITIS; DERIVATIVES; MECHANISMS; INVITRO;
Keywords:
ALZHEIMERS DISEASE; INFLAMMATION; MICROGLIAS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SENILE PLAQUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K. Ishizuka et al., "IDENTIFICATION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN SENILE PLAQUES AND REACTIVE MICROGLIA OF ALZHEIMERS-DISEASE", PSYCHIATRY AND CLINICAL NEUROSCIENCES, 51(3), 1997, pp. 135-138

Abstract

It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatry factor, in response to non-fibrillar beta-amyloid protein. Reactive microglia and inflammatory factors were reported to be present in beta-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques ofbrain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:30:08