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Titolo:
Thrombus-independent humoral mitogenic factors in atherosclerosis and restenosis
Autore:
Heinle, H; Brehme, U;
Indirizzi:
Univ Tubingen, Dept Physiol 1, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 siol 1, D-72076 Tubingen, Germany
Titolo Testata:
PERFUSION
fascicolo: 10, volume: 13, anno: 2000,
pagine: 440 -
SICI:
0935-0020(200010)13:10<440:THMFIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
GER
Soggetto:
SMOOTH-MUSCLE CELLS; NA+-H+ EXCHANGE; NEOINTIMAL FORMATION; MESSENGER-RNA; SIGNAL-TRANSDUCTION; EXPERIMENTAL-MODEL; CONVERTING ENZYME; OXIDATIVE STRESS; VASCULAR INJURY; LINOLEIC-ACID;
Keywords:
smooth muscle proliferation; hormonal mitogens; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Heinle, H Univ Tubingen, Dept Physiol 1, Gmelinstr 5, D-72076 Tubingen, Germany Univ Tubingen Gmelinstr 5 Tubingen Germany D-72076 gen, Germany
Citazione:
H. Heinle e U. Brehme, "Thrombus-independent humoral mitogenic factors in atherosclerosis and restenosis", PERFUSION, 13(10), 2000, pp. 440

Abstract

Hyperplasia of smooth muscle represents an important mechanism contributing to the formation of atherosclerotic lesions as well as of neointima and restenosis after vascular intervention. Cell proliferation is regulated and under the control of a complex system provided among other by growth factors which are produced by cells and secreted locally or by humoral factors ase. g. hormones, neurotransmitters or metabolites. This review summarizes shortly the intracellular mechanisms by which mitogens can influence gen regulation. Further, effects of angiotensin II, endothelin and insulin, as examples, on the growth of smooth muscle cells are described. Of special interest are the contributions on cell proliferation provided by oxidative stress, generated either extra- or intracellularly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:04:57