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Titolo:
Reference intervals for cystatin C in pre- and full-term infants and children
Autore:
Harmoinen, A; Ylinen, E; Ala-Houhala, M; Janas, M; Kaila, M; Kouri, T;
Indirizzi:
Tampere Univ Hosp, Ctr Lab Med, Tampere 33521, Finland Tampere Univ Hosp Tampere Finland 33521 Lab Med, Tampere 33521, Finland Univ Tampere, Sch Med, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 h Med, FIN-33101 Tampere, Finland Tampere Univ Hosp, Dept Pediat, Tampere, Finland Tampere Univ Hosp Tampere Finland v Hosp, Dept Pediat, Tampere, Finland
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 1-2, volume: 15, anno: 2000,
pagine: 105 - 108
SICI:
0931-041X(200011)15:1-2<105:RIFCCI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; SERUM CREATININE; RENAL-FUNCTION; MARKER; BILIRUBIN; SIZE;
Keywords:
cystatin C; creatinine; glomerular filtration rate; reference intervals; renal function tests;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Harmoinen, A Tampere Univ Hosp, Ctr Lab Med, POB 2000, Tampere 33521, Finland Tampere Univ Hosp POB 2000 Tampere Finland 33521 21, Finland
Citazione:
A. Harmoinen et al., "Reference intervals for cystatin C in pre- and full-term infants and children", PED NEPHROL, 15(1-2), 2000, pp. 105-108

Abstract

Cystatin C is a non-glycated, 13-kDa basic protein produced by all nucleated cells. Recent studies have indicated that the plasma concentration of cystatin C is a better marker for glomerular filtration rate (GFR) than plasma creatinine, which is most commonly used for this purpose. We established reference values for plasma cystatin C in pre- or full-term infants and children. For comparison we also measured the creatinine concentration in the same samples. Cystatin C was measured by a commercially available immunoturbidimetric method with a Hitachi 704 analyzer in sera obtained from 58 pre-term infants, 50 full-term infants and 299 older children (132 girls, 167 boys, median age 4.17 years, range 8 days to 16 years). No sex differences were found. The pre-term infants had higher cystatin C concentrations (mean 1.88 mg/l, SD 0.36 mg/l) than the fullterm (mean 1.70 mg/l, SD 0.26 mg/l, P=0.0145). The reference interval for pre-term infants calculated nonparametrically was 1.34-2.57 mg/l and for full-term infants 1.36-2.23 mg/l. The cystatin C concentration decreased rapidly after birth, and above 3 years of age did not depend on age. The reference interval for children 3-16 years of age calculated non-parametrically was 0.51-1.31 mg/l. Younger children (<1 year: 0.75-1.87 mg/l; 1-3 years: 0.68-1.60 mg/l) had slightly, but significantly, higher plasma cystatin C levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:35:43