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Titolo:
Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice
Autore:
Gommans, J; Stolerman, IP; Shoaib, M;
Indirizzi:
Univ London Kings Coll, Inst Psychiat, Sect Behav Pharmacol, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF l, London SE5 8AF, England
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 13, volume: 39, anno: 2000,
pagine: 2840 - 2847
SICI:
0028-3908(2000)39:13<2840:AOTDAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDRO-BETA-ERYTHROIDINE; CONDITIONED TASTE-AVERSIONS; ACETYLCHOLINE-RECEPTOR; SUBUNITS; LACKING; RATS; METHYLLYCACONITINE; SENSITIVITY; BRAIN;
Keywords:
nicotine; drug discrimination; conditioned taste aversion; mice; dihydro-beta-erythroidine; methyllycaconitine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Stolerman, IP Univ London Kings Coll, Inst Psychiat, Sect Behav Pharmacol,De Crespigny Pk, London SE5 8AF, England Univ London Kings Coll De Crespigny Pk London England SE5 8AF
Citazione:
J. Gommans et al., "Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice", NEUROPHARM, 39(13), 2000, pp. 2840-2847

Abstract

Mice of the C5SBL/6J strain were trained to discriminate between nicotine (1.2 mg/kg) and saline in a two-lever drug discrimination procedure under atandem variable-interval 60 s fixed-ratio 10 schedule of food reinforcement. Mice of the same strain were trained in conditioned taste aversion (CTA)experiments where drinking a saccharin or saline solution was paired with injection of nicotine or vehicle. During testing with both flavours presented simultaneously, a reduction in the intake of the nicotine-paired solution indicated CTA. The nicotine discrimination was acquired successfully and nicotine yielded a steep dose-response curve. The competitive nicotinic antagonist dihydro-beta -erythroidine (DH betaE, 0.6-3.0 mg/kg) shifted the dose-response for the discriminative stimulus effect of nicotine to the right; the alpha7 nicotinic receptor antagonist methyllycaconitine (MLA, 1.0-10 mg/kg) had no effect. The mice showed strong CTA to 2.0 mg/kg of nicotine and marginally to 0.6 and 1.2 mg/kg of nicotine. DH betaE (3.0-5.6 mg/kg) attenuated the CTA while MLA (1.0-10 mg/kg) had no effect. These studies showthat nicotine has discriminative and aversive stimulus properties in C57BL/6J mice and that the effects are mediated primarily by receptors sensitiveto DH betaE; there was no evidence for the involvement of alpha7 nicotinicreceptors. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 03/07/20 alle ore 01:25:11