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Titolo:
The antinociceptive effects of alpha 7 nicotinic agonists in an acute painmodel
Autore:
Damaj, MI; Meyer, EM; Martin, BR;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 herapeut, Gainesville, FL 32610 USA
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 13, volume: 39, anno: 2000,
pagine: 2785 - 2791
SICI:
0028-3908(2000)39:13<2785:TAEOA7>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUNGAROTOXIN BINDING-SITES; CENTRAL-NERVOUS-SYSTEM; NUCLEUS RAPHE MAGNUS; ACETYLCHOLINE-RECEPTOR; SPINAL-CORD; SELECTIVE AGONIST; CONSCIOUS RATS; TAIL-FLICK; MICE; RESPONSES;
Keywords:
alpha 7 nicotinic receptors; antinociception; choline; intrathecal; DMXB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, BR Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol &Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 VA 23298 USA
Citazione:
M.I. Damaj et al., "The antinociceptive effects of alpha 7 nicotinic agonists in an acute painmodel", NEUROPHARM, 39(13), 2000, pp. 2785-2791

Abstract

Nicotinic receptors have been found to play a role in modulating pain transmission in the CNS. Activation of cholinergic pathways by nicotine and nicotinic agonists has been shown to elicit antinociceptive effects in a variety of species and pain tests. The involvement of alpha (7) nicotinic receptors in nicotinic analgesia was assessed after spinal (i.t.) and intraventricular (i.c.v.) administration in mice. Dose-dependent antinociceptive effects were seen with the alpha (7) agonist choline after spinal and supraspinal injection using the tail-flick test. Furthermore, alpha (7) antagonists MLA and alpha -BGTX significantly blocked the effects of choline. Dihydro-beta -erythroidine and mecamylamine failed to block choline-induced antinociception. These results strongly support the involvement of alpha (7) subunits in choline's antinociceptive effects. DMXB and 4-OH-DMXB, partial alpha (7) agonists, failed to elicit a significant antinociceptive effect. However, they blocked choline-induced antinociception in a dose-dependent manner following i.t. injection. This antagonism is probably related to their partial agonistic properties of the alpha (7) receptors. These studies suggest that activation of alpha (7) receptors in the CNS elicits antinociceptive effects in an acute thermal pain model. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:23:07