Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery
Autore:
Hasenohrl, RU; De Souza-Silva, MA; Nikolaus, S; Tomaz, C; Brandao, ML; Schwarting, RKW; Huston, JP;
Indirizzi:
Univ Dusseldorf, Inst Physiol Psychol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Ctr Biol & Med Res, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Dept Nucl Med, Dusseldorf, Germany Dept Nucl Med Dusseldorf GermanyDept Nucl Med, Dusseldorf, Germany Univ Brasilia, Neurobiol Lab, Brasilia, DF, Brazil Univ Brasilia BrasiliaDF Brazil ia, Neurobiol Lab, Brasilia, DF, Brazil Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Pret, Psychobiol Lab, Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil hobiol Lab, Ribeirao Preto, Brazil Univ Marburg, Inst Gen & Physiol Psychol, Marburg, Germany Univ Marburg Marburg Germany st Gen & Physiol Psychol, Marburg, Germany
Titolo Testata:
NEUROPEPTIDES
fascicolo: 5, volume: 34, anno: 2000,
pagine: 272 - 280
SICI:
0143-4179(200010)34:5<272:SPAIRI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TACHYKININ NK1 RECEPTOR; NIGROSTRIATAL 6-HYDROXYDOPAMINE LESION; BASALIS MAGNOCELLULARIS REGION; NUCLEUS-ACCUMBENS; VENTRAL PALLIDUM; IN-VIVO; PERIAQUEDUCTAL GRAY; DOPAMINE RELEASE; MAZE PERFORMANCE; LIMBIC REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Huston, JP Univ Dusseldorf, Inst Physiol Psychol, Univ Str 1, D-40225 Dusseldorf, Germany Univ Dusseldorf Univ Str 1 Dusseldorf Germany D-40225 Germany
Citazione:
R.U. Hasenohrl et al., "Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery", NEUROPEPTID, 34(5), 2000, pp. 272-280

Abstract

The neurokinin Substance P (SP) is widely distributed in the central nervous system and has been extensively studied in various functional aspects. This review focuses on the behavioral relevance of SP. Here we show that SP can have memory-promoting, reinforcing and anxiolytic-like effects when administered systemically or into the nucleus basalis of the ventral pallidum. These effects seem to be mediated via the SP-preferring NK, receptor and differentially related to N- versus C-terminal fragments of the undecapeptide. Secondly, SP injection into the ventral pallidum can lead to increases of acetylcholine in frontal cortex and dopamine in nucleus accumbens, suggesting that the hypermnestic, positively reinforcing and anxiolytic effects observed upon basal forebrain injection of SP are mediated by activation of the nucleus accumbens-ventral pallidum circuitry. Furthermore, SP and certain SP-fragments may not only be considered to have beneficial behavioral effects in normal animals, but can also prevent lesion-induced functional deficits and improve the speed of recovery. This indicates that SP agonists might also have a neuroprotective capacity in parallel with recovery-promoting actions. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:06:00