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Titolo:
Effects of ellagic acid by oral administration on N-acetylation and metabolism of 2-aminofluorene in rat brain tissues
Autore:
Lin, SS; Hung, CF; Ho, CC; Liu, YH; Ho, HC; Chung, JG;
Indirizzi:
China Med Coll, Dept Microbiol, Taichung 400, Taiwan China Med Coll Taichung Taiwan 400 Dept Microbiol, Taichung 400, Taiwan Chungtai Inst Hlth Sci & Technol, Dept Radiol Technol, Taichung 400, Taiwan Chungtai Inst Hlth Sci & Technol Taichung Taiwan 400 aichung 400, Taiwan Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan Jen Ai Hosp Taichung Taiwan400 Ai Hosp, Dept Surg, Taichung 400, Taiwan
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 11, volume: 25, anno: 2000,
pagine: 1503 - 1508
SICI:
0364-3190(200011)25:11<1503:EOEABO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTAGENIC ACTIVATION; AROMATIC-AMINES; ACETYLTRANSFERASES; CARCINOGENESIS; MICE;
Keywords:
Ellagic acid; 2-aminofluorene (AF); N-acetyltransferase (NAT); cerebrum; cerebellum; pineal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, JG China Med Coll, Dept Microbiol, 91 Hsueh Shih Rd, Taichung 400, Taiwan China Med Coll 91 Hsueh Shih Rd Taichung Taiwan 400 400, Taiwan
Citazione:
S.S. Lin et al., "Effects of ellagic acid by oral administration on N-acetylation and metabolism of 2-aminofluorene in rat brain tissues", NEUROCHEM R, 25(11), 2000, pp. 1503-1508

Abstract

Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of arylamine carcinogens. Attenuation of liver NAT activity is related to breast and bladder cancer processes. Therefore, the effects of ellagic acid (EA) on the in vitro and in vivo N-acetylation of 2-aminofluorene (AF) were investigated in cerebrum, cerebellum and pineal gland tissues from male Sprague-Dawley rats. For in vitro examination, cytosols with or without EA (0.5-500 muM) co-treatment decreased 7-72%, 15-63% and 10-78% of AF acetylation for cerebrum, cerebellum and pineal gland tissues, respectively. For in vivo examination, EA and AF at the same time treated groups with all 3 examined tissues did show significant differences (the changes of total amounts of AF and AF metabolites based on the Anova analysis) when compared to the ones without EA cotreatment rats. The pretreatment of male rats with EA (10 mg/kg) 24 hr prior to the administration of AF (50 mg/kg) (one day of EA administration suffice to induce large changes in phase II enzyme activity) resulted in a 76% decrease in total AF and metabolites in pineal gland but did not show significant differences in cerebrum and cerebellum tissues. This is the first demonstration to show that EA decreases the N-acetylation of carcinogens in rat brain tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:03:19