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Titolo:
CD27 is required for generation and long-term maintenance of T cell immunity
Autore:
Hendriks, J; Gravestein, LA; Tesselaar, K; van Lier, RAW; Schumacher, TNM; Borst, J;
Indirizzi:
Netherlands Canc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Lab Netherlands Red Cross, Blood Transfus Serv, Dept Immunobiol, NL-1066 CX Amsterdam, Netherlands Lab Netherlands Red Cross Amsterdam Netherlands NL-1066 CX , Netherlands
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 5, volume: 1, anno: 2000,
pagine: 433 - 440
SICI:
1529-2908(200011)1:5<433:CIRFGA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; KAPPA-B ACTIVATION; FACTOR RECEPTOR FAMILY; TNF RECEPTOR; TARGETED DISRUPTION; CD28-DEFICIENT MICE; 4-1BB LIGAND; MEMBER CD27; MURINE CD27; CD40 LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Borst, J Netherlands Canc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX herlands
Citazione:
J. Hendriks et al., "CD27 is required for generation and long-term maintenance of T cell immunity", NAT IMMUNOL, 1(5), 2000, pp. 433-440

Abstract

The Traf-linked tumor necrosis factor receptor family member CD27 is knownas a T cell costimulatory molecule. We generated CD27(-/-) mice and found that CD27 makes essential contributions to mature CD4(+) and CD8(+) T cell function: CD27 supported antigen-specific expansion (but not effector cell maturation) of naive T cells, independent of the cell cycle-promoting activities of CD28 and interleukin 2. Primary CD4(+) and CD8(+) T cell responsesto influenza virus were impaired in CD27(-/-) mice. Effects of deleting the gene encoding CD27 were most profound on T cell memory, reflected by delayed response kinetics and reduction of CD8(+) virus-specific T cell numbersto the level seen in the primary response. This demonstrates the requirement for a costimulatory receptor in the generation of T cell memory.

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Documento generato il 27/09/20 alle ore 00:13:25