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Titolo:
Oxidants, oxidative stress and the biology of ageing
Autore:
Finkel, T; Holbrook, NJ;
Indirizzi:
NHLBI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 BI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NIA, Biol Chem Lab, NIH, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 A, Biol Chem Lab, NIH, Baltimore, MD 21224 USA
Titolo Testata:
NATURE
fascicolo: 6809, volume: 408, anno: 2000,
pagine: 239 - 247
SICI:
0028-0836(20001109)408:6809<239:OOSATB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; TRANSGENIC DROSOPHILA-MELANOGASTER; MANGANESE SUPEROXIDE-DISMUTASE; ACTIVATED PROTEIN-KINASE; EPIDERMAL GROWTH-FACTOR; EXTENDED LIFE-SPAN; CAENORHABDITIS-ELEGANS; HYDROGEN-PEROXIDE; CONTROLLED TRIAL; VITAMIN-E;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Finkel, T NHLBI, Mol Biol Lab, NIH, Bldg 10-6N-240,10 Ctr Dr, Bethesda, MD20892 USA NHLBI Bldg 10-6N-240,10 Ctr Dr Bethesda MD USA 20892 D 20892 USA
Citazione:
T. Finkel e N.J. Holbrook, "Oxidants, oxidative stress and the biology of ageing", NATURE, 408(6809), 2000, pp. 239-247

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:52:30