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Titolo:
A mechanism for modulation of cellular responses to VEGF: Activation of the integrins
Autore:
Byzova, TV; Goldman, CK; Pampori, N; Thomas, KA; Bett, A; Shattil, SJ; Plow, EF;
Indirizzi:
Cleveland Clin Fdn, Joseph J Jacobs Ctr Thrombosis & Vasc Biol, Cleveland,OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 sc Biol, Cleveland,OH 44195 USA Cleveland Clin Fdn, Dept Mol Cardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Cell Biol, Cleveland, OH 44195 USA Cleveland ClinFdn Cleveland OH USA 44195 l Biol, Cleveland, OH 44195 USA Scripps Clin & Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Med, La Jolla, CA 92037 USA Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486 Dept Canc Res, W Point, PA 19486 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 6, anno: 2000,
pagine: 851 - 860
SICI:
1097-2765(200010)6:4<851:AMFMOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; ALPHA-V INTEGRINS; ALPHA(V)BETA(3) INTEGRIN; ALPHA-V-BETA-3 INTEGRIN; BETA-1 INTEGRIN; BONE-RESORPTION; ANGIOGENESIS; EXPRESSION; OSTEOPONTIN; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Byzova, TV Cleveland Clin Fdn, Joseph J Jacobs Ctr Thrombosis & Vasc Biol,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 5 USA
Citazione:
T.V. Byzova et al., "A mechanism for modulation of cellular responses to VEGF: Activation of the integrins", MOL CELL, 6(4), 2000, pp. 851-860

Abstract

Many similarities exist in the cellular responses elicited by VEGF and governed by integrins. Here, we identify a basis for these interrelationships:VEGF activates integrins. VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenovirus gene transfer mediated by alpha (v)beta (3) and also activated other integrins, alpha (v)beta (5), alpha (5)beta (1), and alpha (2)beta (1), involved in angiogenesis. Certain tumor cells exhibited high spontaneous adhesion and migration, which were attributable to a VEGF-dependent autocrine/paracrine activation of integrins. This activation was mediated by the VEGFR2 receptor and regulated via phosphatidylinositol-3-kinase, Akt, and the PTEN signaling axis. Thus, integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:58:47