Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of estrogen on intestinal strontium absorption in postmenopausal women
Autore:
Bolscher, MDT; Neele, SJM; Barto, R; van der Vijgh, WJF; Netelenbos, JC;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Endocrinol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Clin Res Lab Internal Med, NL-1081 HV Amsterdam,Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV am,Netherlands
Titolo Testata:
MATURITAS
fascicolo: 3, volume: 36, anno: 2000,
pagine: 195 - 201
SICI:
0378-5122(20001031)36:3<195:EOEOIS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; CALCIUM-ABSORPTION; SERUM 1,25-DIHYDROXYVITAMIN-D; RAT; 17-BETA-ESTRADIOL; OSTEOPOROSIS; METABOLISM; GENOTYPES; YOUNG; AGE;
Keywords:
estrogen; osteoporosis; strontium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Netelenbos, JC Free Univ Amsterdam Hosp, Dept Endocrinol, Room Br 232,Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp RoomBr 232,Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
M.D.T. Bolscher et al., "Effect of estrogen on intestinal strontium absorption in postmenopausal women", MATURITAS, 36(3), 2000, pp. 195-201

Abstract

Objectives: there is considerable uncertainty about the underlying cause of decreased intestinal calcium absorption that occurs in postmenopausal women. In a previous study, estrogen treatment did not result in an increased intestinal calcium absorption using strontium as a marker. A possible explanation could be that the calcium/strontium load given to the women was too high (similar to 600 mg Ca), which might result in an insensitive test withrespect to the possible stimulation of active strontium transport by estrogen. Therefore, the purpose of this study was to reinvestigate the effect of estrogen on active intestinal strontium absorption using a load of 2.5 mmol of strontium only. Method's: the effect of estrogen on intestinal strontium absorption was measured in eight normal postmenopausal women. The studyincluded two baseline strontium absorption tests, which were performed with an interval of 10 days for calculating the within subject Variation (SER). Thereafter the effect of 2 months of estrogen treatment on intestinal strontium absorption was assessed. Fractional absorption (FC,,,) and the area under the concentration time curve (AUC) 4 h after an oral strontium load of 2.5 mmol were calculated. Results: the within subject SER of FC240 and AUC(0-240) were 2.3 +/- 0.76 and 1.2 +/- 0.41, respectively. FC240 and AUC(0-240) of strontium were unchanged after treatment with estrogen. Conclusions: in normal postmenopausal women, we did not find a modulating effect of short-term treatment with a (supra) physiological dose of estrogen on intestinal calcium absorption as measured by the strontium absorption test. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:21:01