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Titolo:
Hormonal replacement therapy reduces forearm fracture incidence in recent postmenopausal women - results of the Danish Osteoporosis Prevention Study
Autore:
Mosekilde, L; Beck-Nielsen, H; Sorensen, OH; Nielsen, SP; Charles, P; Vestergaard, P; Hermann, AP; Gram, J; Hansen, TB; Abrahamsen, B; Ebbesen, EN; Stilgren, L; Jensen, LB; Brot, C; Hansen, B; Tofteng, CL; Eiken, P; Kolthoff, N;
Indirizzi:
Aarhus Univ Hosp, Aarhus Kommune Hosp, Osteoporosis Clin, Dept Endocrinol & Metab, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C nol & Metab, DK-8000 Aarhus C, Denmark Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 ocrinol, DK-5000 Odense, Denmark Copenhagen Municipal Hosp, Copenhagen, Denmark Copenhagen Municipal Hosp Copenhagen Denmark Hosp, Copenhagen, Denmark Hillerod Hosp, Hillerod, Denmark Hillerod Hosp Hillerod DenmarkHillerod Hosp, Hillerod, Denmark
Titolo Testata:
MATURITAS
fascicolo: 3, volume: 36, anno: 2000,
pagine: 181 - 193
SICI:
0378-5122(20001031)36:3<181:HRTRFF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIMENOPAUSAL WOMEN; VERTEBRAL FRACTURES; RANDOMIZED TRIAL; ESTROGEN; RISK; HRT; MENOPAUSE; DISEASE;
Keywords:
hormonal replacement therapy; fractures; oestrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Vestergaard, P Aarhus Univ Hosp, Aarhus Kommune Hosp, Osteoporosis Clin, Dept Endocrinol & Metab, Tage Hansens Gade 2, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Tage Hansens Gade 2 Aarhus Denmark C mark
Citazione:
L. Mosekilde et al., "Hormonal replacement therapy reduces forearm fracture incidence in recent postmenopausal women - results of the Danish Osteoporosis Prevention Study", MATURITAS, 36(3), 2000, pp. 181-193

Abstract

Objectives: To study the fracture reducing potential of hormonal replacement therapy (HRT) in recent postmenopausal women in a primary preventive scenario. Methods: Prospective controlled comprehensive cohort trial: 2016 healthy women aged 45-58 years, from three to 24 months past last menstrual bleeding were recruited from a random sample of the background population. Mean age was 50.8 +/- 2.8 years, and the number of person years followed was 9335.3. There were two main study arms: a randomised arm (randomised to HRT; n = 502, or not; II = 504) and a non-randomised arm (on HRT: n = 221, or not; n = 789 by own choice). First line HRT was oral sequential oestradiol/norethisterone in women with intact uterus and oral continuous oestradiol in hysterectomised women. Results: After five years, a total of 156 fractures were sustained by 140 women. There were 51 forearm Fractures in 51 women. By intention-to-treat analysis (n = 2016), overall fracture risk was borderline statistically significantly reduced (RR = 0.73, 95% CI: 0.50-1.05), and forearm fracture risk was significantly reduced (RR = 0.45, 95% CI: 0.22-0.90) with HRT. Restricting the analysis to women who had adhered to theirinitial allocation of either HRT (n = 395) or no HRT (n = 977) showed a significant reduction in both the overall fracture risk (RR = 0.61, 95% CI: 0.39-0.97) and the risk of forearm fractures (RR = 0.24, 95% CI: 0.09-0.69). Compliance with HRT was 65% after five years. Conclusions: It is possible to reduce the number of forearm fractures and possibly the total number of fractures in recent postmenopausal women by use of HRT as primary prevention. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:08:44