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Titolo:
Glomerular size in renal dysplasia secondary to obstructive uropathy: A further exploration of the fetal lamb model
Autore:
Kitagawa, H; Pringle, KC; Zuccollo, J; Koike, J; Nakada, K; Ikoma, M; Seki, Y;
Indirizzi:
St Marianna Univ, Sch Med, Div Pediat Surg, Dept Pathol,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan St Marianna Univ, Sch Med, Div Pediat Surg, Dept Pediat,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan Wellington Sch Med, Dept Surg, Wellington, New Zealand Wellington Sch MedWellington New Zealand Surg, Wellington, New Zealand Wellington Sch Med, Dept Obstet & Gynecol, Wellington, New Zealand Wellington Sch Med Wellington New Zealand ecol, Wellington, New Zealand
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 11, volume: 35, anno: 2000,
pagine: 1651 - 1655
SICI:
0022-3468(200011)35:11<1651:GSIRDS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE URETHRAL OBSTRUCTION; PRUNE-BELLY-SYNDROME; 14 WEEKS GESTATION; KIDNEY-DISEASE; PATHOGENESIS; FETUS;
Keywords:
multicystic dysplastic kidney; fetal obstructive uropathy; mean planar area of glomeruli; fetal surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kitagawa, H St Marianna Univ, Sch Med, Div Pediat Surg, Dept Pathol,Miyamae Ku, 2-16-1Sugao, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ 2-16-1 Sugao Kawasaki Kanagawa Japan 2168511
Citazione:
H. Kitagawa et al., "Glomerular size in renal dysplasia secondary to obstructive uropathy: A further exploration of the fetal lamb model", J PED SURG, 35(11), 2000, pp. 1651-1655

Abstract

Background/Purpose: Creating an obstructive uropathy early in glomerulogenesis would produce multicystic dysplastic kidneys (MCDK). Measuring the mean planar area of the glomeruli (GMPA) may clarify the pathogenesis of MCDK. Methods: Fetal lambs at 60 days' gestation had their left ureter ligated and were delivered by cesarian section at 145 days' gestation. Kidney weightand length were recorded. GMPA in 3 zones (outer, middle, inner) of the sectioned kidney was measured using a computerized planimeter. The obstructedkidneys were compared with contralateral unobstructed kidneys. The unpaired Student's t test was used to determine significance. Results: One ewe miscarried. Four of 5 (80%) 60-day lambs survived. All had dysplastic kidneys. Mean kidney weights were 4.3 +/- 0.84 g in MCDK and 16.8 +/- 3.6 g in controls (P < .05). The GMPA of the outer, middle, and inner zones of the MCDK were 2.7 x 10(-3) mm(2), 3.2 x 10(-3) mm(2), and 4.0 x10(-3) mm2, respectively. Controls were 2.8 x 10(-3)mm(2), 4.4 X 10(-3) mm(2), and 6.0 x 10(-3) mmz. The glomeruli of 60-day fetal kidneys were 3.0 x10(-3) mm(2), 6.1 x 10(-3) mm(2), and 11.0 x 10(-3) mm(2). MCDK had smaller glomeruli in the inner and middle zones than controls. Conclusion: Fetal glomeruli appear to grow from the inner zone of the kidney. Early urinary tract obstruction stops this growth. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/10/20 alle ore 06:32:53