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Titolo:
Early fetal obstructive uropathy produces Potter's syndrome in the lamb
Autore:
Kitagawa, H; Pringle, KC; Zuccollo, J; Koike, J; Nakada, K; Moriya, H; Seki, Y;
Indirizzi:
St Marianna Univ, Sch Med, Div Pediat Surg, Dept Pathol,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan Wellington Sch Med, Dept Surg, Wellington, New Zealand Wellington Sch MedWellington New Zealand Surg, Wellington, New Zealand Wellington Sch Med, Dept Obstet & Gynecol, Wellington, New Zealand Wellington Sch Med Wellington New Zealand ecol, Wellington, New Zealand
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 11, volume: 35, anno: 2000,
pagine: 1549 - 1553
SICI:
0022-3468(200011)35:11<1549:EFOUPP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
Potter's syndrome; fetal obstructive uropathy; dysplastic kidney; fetal surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kitagawa, H St Marianna Univ, Sch Med, Div Pediat Surg, Dept Pathol,Miyamae Ku, 2-16-1Sugao, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ 2-16-1 Sugao Kawasaki Kanagawa Japan 2168511
Citazione:
H. Kitagawa et al., "Early fetal obstructive uropathy produces Potter's syndrome in the lamb", J PED SURG, 35(11), 2000, pp. 1549-1553

Abstract

Background: If creating an obstructive uropathy early in glomerulogenesis produces MCDK (Multicystic Dysplastic Kidney), then a very early obstruction may produce Potter's Syndrome (PS) with oligohydramnios,Methods: Fetal lambs at 50 days' gestation underwent urethral and urachal ligation using fine SILASTIC(R) (Dow Corning, Midland, MI) tubing and were delivered by cesarean section at 145 days' gestation. At the time of death,kidney weight, length, and lung volumes were measured. These samples were examined histologically. Urinary sodium, chloride, potassium, and osmolarity also were measured. These were compared with normal-term fetuses. Results: One ewe miscarried. Two of 3 of 50-day obstructive uropathy lambssurvived. The 2 survivors had dysplastic kidneys. One with large gastroschisis did not have PS but the other had renal, pulmonary, and chest wall hypoplasia. Both male lambs had undescended testes with a large bladder. Kidney weights were 2 g in the PS lamb and 16 g in controls. Lung volume was 84 mt in the PS lamb and 340 mt in controls. The lamb's face was compressed and the fetus was hydropic. Urine sodium, potassium, and osmolarity levels were higher than that of controls. Conclusions: This is the first successful model ligating the penile urethra and urachus in a 50-day lamb. The authors' previous 60-day model did not have PS, but an earlier obstructive uropathy caused MCDK with PS. Copyright(C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:58:46