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Titolo:
Ancistrolikokines A-C: New 5,8 '-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko
Autore:
Bringmann, G; Gunther, C; Saeb, W; Mies, J; Wickramasinghe, A; Mudogo, V; Brun, R;
Indirizzi:
Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 n Chem, D-97074 Wurzburg, Germany Univ Kinshasa, Fac Sci, Kinshasa, Zaire Univ Kinshasa Kinshasa ZaireUniv Kinshasa, Fac Sci, Kinshasa, Zaire Univ Peradeniya, Dept Chem, Peradeniya, Sri Lanka Univ Peradeniya Peradeniya Sri Lanka , Dept Chem, Peradeniya, Sri Lanka Schweizer Tropeninst, CH-4002 Basel, Switzerland Schweizer Tropeninst Basel Switzerland CH-4002 H-4002 Basel, Switzerland
Titolo Testata:
JOURNAL OF NATURAL PRODUCTS
fascicolo: 10, volume: 63, anno: 2000,
pagine: 1333 - 1337
SICI:
0163-3864(200010)63:10<1333:AAN5'N>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM; KORUPENSIS; MICHELLAMINES; ISOQUINOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bringmann, G Univ Wurzburg, Inst Organ Chem, Hubland, D-97074 Wurzburg, Germany Univ Wurzburg Hubland Wurzburg Germany D-97074 burg, Germany
Citazione:
G. Bringmann et al., "Ancistrolikokines A-C: New 5,8 '-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko", J NAT PROD, 63(10), 2000, pp. 1333-1337

Abstract

Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodiumfalciparum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:02:14