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Titolo:
Endothelin-1 and right-sided heart failure in rats: Effects of an endothelin receptor antagonist on the failing right ventricle
Autore:
Miyauchi, T; Sato, R; Sakai, S; Kobayashi, T; Ueno, M; Kondo, H; Kawano, S; Goto, K; Yamaguchi, I;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Bristol Myers Squibb KK, Kanagawa, Japan Bristol Myers Squibb KK Kanagawa Japan Myers Squibb KK, Kanagawa, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
, volume: 36, anno: 2000, supplemento:, 1
pagine: S327 - S330
SICI:
0160-2446(2000)36:<S327:EARHFI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-HYPERTENSION; VASOCONSTRICTOR PEPTIDE; ENDOGENOUS ENDOTHELIN-1; CARDIAC-FUNCTION; EXPRESSION; MYOCYTES; HYPERTROPHY; INCREASE; SURVIVAL;
Keywords:
endothelin-1 (ET-1); right-sided heart failure; pulmonary hypertension (PH); ETA-receptor antagonist; molecular marker for failing heart;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Miyauchi, T Univ Tsukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 aki 3058575, Japan
Citazione:
T. Miyauchi et al., "Endothelin-1 and right-sided heart failure in rats: Effects of an endothelin receptor antagonist on the failing right ventricle", J CARDIO PH, 36, 2000, pp. S327-S330

Abstract

The development of pulmonary hypertension (PH) causes right-sided heart failure. We investigated whether chronic treatment with the endothrlin-A- (ETA) receptor antagonist EMS-193884 in rats with monocrotaline-(MCT) induced PH improves right-sided heart failure. Administration of BMS-193884 (100 mg/kg) was cormmenced on the day before treatment with MCT. At 19 days, hemodynamics were measured under anesthesia and hearts were removed. The right ventricular systolic pressure (RVSP), an indicator for pulmonary hypertension, was remarkably elevated in the PH group compared with the normal controlgroup. EMS-193884 effectively prevented this elevation. The central venouspressure, an indicator for right-sided heart failure, was markedly increased in the PH group, This increase was reduced to the normal level by BMS-193884. In the failing right ventricle of the PH group, the expression of atrial natriuretic peptide (ANP) mRNA, which is a molecular marker fur the failing heart, was markedly increased. EMS-193884 greatly prevented this increase. The present study suggests that ET-1 contributes to the right-sided heart failure caused by PH and that an ETA-receptor antagonist is a beneficial drug which improves both hemodynamics and cardiac gene expression in the failing right ventricle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:46:14