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Titolo:
Biphasic release of immunoreactive endothelins following acute pulmonary thromboembolism in pigs
Autore:
Tsang, J; Battistini, S; Dussault, P; Stewart, K; Qayumi, KA;
Indirizzi:
Univ British Columbia, Pulm Res Lab, Dept Med, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 ver, BC V6Z 1Y6, Canada Univ British Columbia, Dept Surg, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 ver, BC V6Z 1Y6, Canada Univ Laval, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 niv Laval, St Foy, PQ G1K 7P4, Canada
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
, volume: 36, anno: 2000, supplemento:, 1
pagine: S221 - S224
SICI:
0160-2446(2000)36:<S221:BROIEF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE FLUID; AIR-FLOW OBSTRUCTION; EMBOLISM; HYPERTENSION; EXPRESSION; ASTHMA; LUNGS; MEDIATORS; DISEASE;
Keywords:
pulmonary embolism; pulmonary hypertension; endothelins (ETs); vascular damage; thrombin; hypoxemia; ventilation perfusion mismatch;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tsang, J Univ British Columbia, Pulm Res Lab, Dept Med, 1081 Burrard St, Vancouver,BC V6Z 1Y6, Canada Univ British Columbia 1081 Burrard St VancouverBC Canada V6Z 1Y6
Citazione:
J. Tsang et al., "Biphasic release of immunoreactive endothelins following acute pulmonary thromboembolism in pigs", J CARDIO PH, 36, 2000, pp. S221-S224

Abstract

The purpose of this investigation was to study the role of endothelins (ETs) in the pathogenesis of acute pulmonary thromboembolism (PTE). Eighteen piglets (20 +/- 3 kg) were anesthetized and ventilated with 100% oxygen, five of them then served as controls. Acute thromboembolic injury in the lung was induced by injecting 15-25 ml of preformed clots into the left lower lobar pulmonary artery during thoracotomy. Pulmonary arterial pressure (Ppa) increased by at least 2.5-fold from baseline. During the subsequent 8 h, seven blood samples were collected from the left atrium and assayed for immunoreactive ETs. The results showed that following PTE: (1) Ppa remained elevated but cardiac output remained constant throughout the experiments; (2) plasma level of immunoreactive ETs increased in the embolized group comparedto controls and the profile of immunoreactive ET release suggested a biphasic response. We conclude that the release of these vasocontractile and bronchoconstrictive mediators after PTE may contribute to ventilation perfusion mismatching and account for the pulmonary hypertension and deterioration of gas exchange that are often seen clinically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:15:44