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Titolo:
Gender differences in hemodynamic responses to endothelin-1
Autore:
Tatchum-Talom, R; Martel, C; Labrie, C; Labrie, F; Marette, A;
Indirizzi:
Univ Laval Hosp, Res Ctr, Dept Physiol, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp St Foy PQ Canada G1V 4G2 siol, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp, Res Ctr, Lipid Res Unit, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp St Foy PQ Canada G1V 4G2 Unit, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp, Res Ctr, Mol Endocrinol Lab, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp St Foy PQ Canada G1V 4G2 Lab, St Foy, PQ G1V 4G2, Canada
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
, volume: 36, anno: 2000, supplemento:, 1
pagine: S102 - S104
SICI:
0160-2446(2000)36:<S102:GDIHRT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN;
Keywords:
sex; estrogens; blood pressure; hindlimb blood flow; endothelin-1 (ET-1);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Marette, A Univ Laval Hosp, Res Ctr, Dept Physiol, 2705 Blvd Laurier, St Foy, PQ G1V 4G2, Canada Univ Laval Hosp 2705 Blvd Laurier St Foy PQ Canada G1V 4G2 nada
Citazione:
R. Tatchum-Talom et al., "Gender differences in hemodynamic responses to endothelin-1", J CARDIO PH, 36, 2000, pp. S102-S104

Abstract

We investigated whether gender affects the presser and constrictor effectsof endothelin-1 (ET-1) in anesthetized rats. Baseline values for arterial blood pressure (mmHg) and hindquarter resistance (HQR, mmHg/ml/min/100 g), respectively, were similar in male (96.0 +/- 3.1 and 13.9 +/- 0.6) and female (103.1 +/- 5.6 and ;12.8 +/- 23) rats. ET-1 (1 and 3 mug/kg) produced rapid and transient falls in arterial blood pressure and HQR, followed by long-lasting increases in blood pressure and HQR. The initial ET-1-induced hypotension and vasodilation were similar in both groups. However, the presserand hindquarter vasoconstrictor effects were significantly higher (p < 0.05) in male than female rats. Thus, the increases in blood pressure and HQR to ET-1 (3 <mu>g/kg) were attenuated in female (+15.3 +/- 3.4 mnHg and +3.7+/- 1.6 mmHg/ml/min/100 g) compared to male (+24.9 +/- 2.3 mnHg and +8.0 +/- 1.6 mmHg/ml/min/100 g) rats. These results indicate that there is a gender difference in the vasoconstrictor, but not the vasodilator effects of ET-1. We suggest that the lower ET-1-induced hypertension and hindlimb vasoconstrictions observed in female rats may be responsible for the lower risk of developing coronary heart disease in premenopausal women.

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Documento generato il 20/09/20 alle ore 23:20:43