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Titolo:
In vivo assessment of cardiac remodeling after myocardial infarction in rats by cine-magnetic resonance imaging
Autore:
Nahrendorf, M; Wiesmann, F; Hiller, KH; Han, H; Hu, K; Waller, C; Ruff, J; Haase, A; Ertl, G; Bauer, WR;
Indirizzi:
Univ Wurzburg, Med Klin, Dept Med, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 pt Med, D-97080 Wurzburg, Germany Univ Wurzburg, Dept Biophys EP5, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ys EP5, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
fascicolo: 3, volume: 2, anno: 2000,
pagine: 171 - 180
SICI:
1097-6647(2000)2:3<171:IVAOCR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR-FUNCTION; DYSFUNCTION; RESPONSES; PRESSURE; VOLUMES; HEARTS; SIZE; MASS;
Keywords:
infarct size; hypertrophy; MRI; myocardial infarction; pressure-volume curves; rat; remodeling; ventricular function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, WR Univ Wurzburg, Med Klin, Dept Med, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 ny
Citazione:
M. Nahrendorf et al., "In vivo assessment of cardiac remodeling after myocardial infarction in rats by cine-magnetic resonance imaging", J CARD M RE, 2(3), 2000, pp. 171-180

Abstract

The rat infarct model offers important parallels to the process of remodeling after myocardial infarction (MI) in humans. The aim of this study was to test the feasibility of cine fast low-angle shot (FLASH) magnetic resonance imaging (MRI) for assessment of the infarcted and noninfarcted rat heartand to compare the results with established methods. In gruoup A, MRI was done 8-16 weeks after MI on a 7-T scanner using an electrocardiogram-triggered cine-FLASH sequence. We determined left ventricular (LV) volumes and mass, wall thickness, MI size, cardiac output, and ejection fraction. Afterward, MI size was histologically determined. In group B, after MRI eight controls and eight rats 16 weeks after MI underwent conventional hemodynamic measurements for determination of cardiac output, LV volumes, and ejection fraction by electromagnetic flowmeter and pressure-volume curves. LV wet weight was determined In group A, MRI-acquired MI size (18.5 +/- 2%) was smaller than histology (22.8 +/- 2.5%, p < 0.05) with close correlation (r = 0.97). In group B, agreement in LV mass was found between MRI and wet weight (controls, 537.6 +/- 19.6 vs. 540.3 +/- 18.4 mg; MI, 865.1 +/- 39.2 vs. 865.1+/- 41.3 mg; for the difference p = ns, r = 0.97, p < 0.05) and in the MRIand flowmeter measurements (cardiac output, controls 73.1 +/- 2.9 vs. 75.2+/- 2.6 ml/min; MI 82.4 +/- 5.2 vs. 81.9 +/- 3.7 ml/min; for the difference p = ns, r = 0.80, p < 0.05). End-diastolic volume by MRI differed from pressure-volume curves with good correlation (controls, 343.9 +/- 8.4 vs. 262.7 +/- 12.8 <mu>l; MI, 737.0 +/- 70.5 vs. 671.1 +/- 64.1 mul; p < 0.05 each, r = 0.96, p < 0.05). Cine-FLASH-MRI is a valuable diagnostic tool applicable to the vat model of MI. Being noninvasive and exact it offers new insights in the remodeling process after MI because serial measurements are possible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:26:01