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Titolo:
Submandibular secretory and vascular responses to stimulation of the parasympathetic innervation in anesthetized cats
Autore:
Rourke, K; Edwards, AV;
Indirizzi:
Univ Cambridge, Physiol Lab, Cambridge CB2 3EG, England Univ Cambridge Cambridge England CB2 3EG Lab, Cambridge CB2 3EG, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 89, anno: 2000,
pagine: 1964 - 1970
SICI:
8750-7587(200011)89:5<1964:SSAVRT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; BLOOD-FLOW; VASODILATOR RESPONSES; NITRIC-OXIDE; CELL-VOLUME; GLAND; ENDOTHELIN; PEPTIDE;
Keywords:
blood flow; secretion; protein; saliva;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Edwards, AV Univ Cambridge, Physiol Lab, Downing St, Cambridge CB2 3EG, England Univ Cambridge Downing St Cambridge England CB2 3EG , England
Citazione:
K. Rourke e A.V. Edwards, "Submandibular secretory and vascular responses to stimulation of the parasympathetic innervation in anesthetized cats", J APP PHYSL, 89(5), 2000, pp. 1964-1970

Abstract

Submandibular secretory responses to stimulation of the parasympathetic chorda-lingual nerve in anaesthetized cats have been investigated before, during, and after intracarotid infusion of endothelin-l (ET-1), which reduced blood flow through the gland by 64 +/- 7%. Stimulation at different frequencies (2, 4, 8, and 16 Hz) evoked a frequency-dependent increase in the flowof submandibular saliva, sodium concentration and output, and output of both potassium and protein. The reduction in submandibular blood flow, which occurred in response to the infusion of ET-1, was associated with a decreased flow of saliva and a diminished output of both sodium and protein. The flow of saliva was linearly related to submandibular blood flow both in the presence and absence of ET-1. It is concluded that submandibular secretory responses to electrical stimulation of the parasympathetic innervation can be significantly attenuated by reducing the blood flow through the gland byET-1 infusion, just as it is when the blood flow is reduced by hypotension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:19:20