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Titolo:
Effect of L-arginine on endothelial injury and hemostasis in rabbit endotoxin shock
Autore:
Wiel, E; Pu, Q; Corseaux, D; Robin, E; Bordet, R; Lund, N; Jude, B; Vallet, B;
Indirizzi:
Lille Univ Hosp, Dept Anesthesiol, F-59037 Lille, France Lille Univ Hosp Lille France F-59037 Anesthesiol, F-59037 Lille, France Lille Univ Hosp, Dept Pharmacol, F-59037 Lille, France Lille Univ Hosp Lille France F-59037 pt Pharmacol, F-59037 Lille, France Lille Univ Hosp, Dept Hematol, F-59037 Lille, France Lille Univ Hosp Lille France F-59037 Dept Hematol, F-59037 Lille, France Univ Rochester, Dept Anesthesiol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 nesthesiol, Rochester, NY 14642 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 89, anno: 2000,
pagine: 1811 - 1818
SICI:
8750-7587(200011)89:5<1811:EOLOEI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; HYPERCHOLESTEROLEMIC RABBIT; TISSUE FACTOR; SEPTIC SHOCK; SEPSIS; INHIBITION; RESPONSES; SURVIVAL; AORTA; MODEL;
Keywords:
endothelium; endotoxic shock; lipopolysaccharide; N-G-nitro-L-arginine; methyl ester; tissue factor; monocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Vallet, B CH, Dept Anesthesie Reanimat, Rue Michel Polonovski, F-59037 Lille, France CH Rue Michel Polonovski Lille France F-59037 037 Lille, France
Citazione:
E. Wiel et al., "Effect of L-arginine on endothelial injury and hemostasis in rabbit endotoxin shock", J APP PHYSL, 89(5), 2000, pp. 1811-1818

Abstract

To investigate whether impaired endothelial function was related to alteration of nitric oxide (NO) formation during endotoxic shock, we studied the effects of supplementation of L-arginine (L-Arg), D-arginine (D-Arg), and NG-nitro-L-arginine methyl ester (L-NAME), on endothelial function and structure in a rabbit model. Endotoxic shock was induced by a single lipopolysaccharide bolus (0.5 mg/kg iv, Escherichia coli endotoxin). Coagulation factors and expression of monocyte tissue factor were determined by functional assays. Endothelium-dependent vascular relaxation was assessed by in vitro vascular reactivity. Immunohistochemical staining (CD31) was performed to assess damaged endothelial cell surface of the abdominal aorta. These parameters were studied 5 days after the onset of endotoxic shock and were compared under three conditions: in absence of treatment, with L-Arg or D-Arg supplementation, or with L-NAME. Both L-Arg and D-Arg significantly improved endothelium-dependent relaxation and endothelial morphological injury. L-NAMEdid not alter endothelial histological injury induced by lipopolysaccharide. These data indicate that arginine supplementation nonspecifically prevents endothelial dysfunction and histological injury in rabbit endotoxic shock. Moreover, L-Arg has no effect on coagulation activation and expression of monocyte tissue factor induced by endotoxic shock.

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Documento generato il 26/09/20 alle ore 02:32:01