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Titolo:
Evidence for the existence of insect defensin-like peptide in scorpion venom
Autore:
Zhu, SY; Li, WX; Jiang, DH; Zeng, XC;
Indirizzi:
Wuhan Univ, Coll Life Sci, Dept Biotechnol, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 l, Wuhan 430072, Peoples R China
Titolo Testata:
IUBMB LIFE
fascicolo: 1, volume: 50, anno: 2000,
pagine: 57 - 61
SICI:
1521-6543(200007)50:1<57:EFTEOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICH ANTIMICROBIAL PEPTIDES; BUTHUS-MARTENSII KARSCH; K+ CHANNELS; TOXINS; GENES;
Keywords:
Buthus martensii Karsch; gene; insect defensin; scorpion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Li, WX Wuhan Univ, Coll Life Sci, Dept Biotechnol, Wuhan 430072, Peoples RChina Wuhan Univ Wuhan Peoples R China 430072 n 430072, Peoples R China
Citazione:
S.Y. Zhu et al., "Evidence for the existence of insect defensin-like peptide in scorpion venom", IUBMB LIFE, 50(1), 2000, pp. 57-61

Abstract

Insect defensin refers to a group of antibacterial peptides derived from avariety of insect species as well as from scorpion and possessing a three-dimensional structure highly similar to that of scorpion toxins. A full-length cDNA encoding an insect defensin-like peptide was isolated from the venom gland cDNA library of the Chinese scorpion Buthus martensii Karsch, The precursor, the overall organization of which is similar to that of insect defensins, consists of 61 amino acid residues with a putative signal peptideof 15 residues, a propeptide of 7 residues, and a mature peptide of 39 residues (named BmTXKS2), The positions of six cysteines and a conserved glycine in mature BmTXKS2 are the same as those in LqDef, the first defensin found in scorpions, which suggests these peptides should present a similar cysteine-stabilized alpha beta motif. Phylogenetic analysis further shows thatthe structure of BmTXKS2 is closer to that of ancient defensins (e.g., LqDef and AaDef, two insect defensins present in the scorpion hemolymph) than to scorpion toxins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:47:32