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Titolo:
Sensory capacity of the Royal College of Surgeons rat
Autore:
Hetherington, L; Benn, M; Coffey, PJ; Lund, RD;
Indirizzi:
Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England UnivSheffield Sheffield S Yorkshire England S10 2TP S Yorkshire, England Univ Coll London, Inst Ophthalmol, London, England Univ Coll London London England ondon, Inst Ophthalmol, London, England
Titolo Testata:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
fascicolo: 12, volume: 41, anno: 2000,
pagine: 3979 - 3983
SICI:
0146-0404(200011)41:12<3979:SCOTRC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUPILLARY LIGHT REFLEX; INHERITED RETINAL DYSTROPHY; MACULAR DEGENERATION; PIGMENT EPITHELIUM; SUPERIOR COLLICULUS; POSSIBLE MECHANISMS; TRANSPLANTATION; CORTEX; RCS; INTENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Coffey, PJ Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TP, S Yorkshire, England Univ Sheffield Western Bank Sheffield S Yorkshire England S10 2TP
Citazione:
L. Hetherington et al., "Sensory capacity of the Royal College of Surgeons rat", INV OPHTH V, 41(12), 2000, pp. 3979-3983

Abstract

PURPOSE. To apply noninvasive tests for examining visual and other sensoryfunctions of pigmented Royal College of Surgeons (RCS) rats compared with pigmented and albino control animals. METHODS. Rats aged 3 and 7 months were tested with a general neurologic examination that assessed visual, auditory, tactile, and whisker displacementresponses. Photophobic responses and visual discrimination were also measured. RESULTS. Dystrophic RCS rats failed the visual presentation tests, even at3 months of age, and showed diminished performance on tactile tests. Auditory and whisker displacement performances were normal. Albino rats also showed diminished performance on the visual test, particularly to stimuli presented in the upper visual field. Photophobic responses were diminished in the dystrophic RCS rats compared with the pigmented control animals. Albino animals showed heightened photophobia. The dystrophic rats failed to reach criterion levels of performance on the visual discrimination test even withgratings of 0.045 cyc/deg. CONCLUSIONS. The tests used discriminate deteriorated complex visual functions in RCS rats at ages when some simple reflexes can still be demonstrated. As such, they provide easily executed tests for screening for the effects of reparative treatments such as transplantation, administration of growth factors, and gene transfer technology. The integrity of whisker and auditory function are important when using tests requiring polysensory inputs. The somatosensory defect is surprising but may be useful in searching for the gene locus of the retinal disorder. The aberrations seen in the albino rats may be attributable to the effects of light damage and unfiltered light.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 14:07:37