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Titolo:
High blood cortisol levels and low cortisol receptor affinity: Is the chub, Leuciscus cephalus, a cortisol-resistant teleost?
Autore:
Pottinger, TG; Carrick, TR; Appleby, A; Yeomans, WE;
Indirizzi:
NERC, Ctr Ecol & Hydrol, Windermere Lab, Ambleside LA22 0LP, Cumbria, England NERC Ambleside Cumbria England LA22 0LP leside LA22 0LP, Cumbria, England Environm Agcy, Natl Salmon & Trout Fisheries Ctr, Cardiff CF3 0LT, S Glam,Wales Environm Agcy Cardiff S Glam Wales CF3 0LT Cardiff CF3 0LT, S Glam,Wales
Titolo Testata:
GENERAL AND COMPARATIVE ENDOCRINOLOGY
fascicolo: 1, volume: 120, anno: 2000,
pagine: 108 - 117
SICI:
0016-6480(200010)120:1<108:HBCLAL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMO-TRUTTA-L; PITUITARY-INTERRENAL AXIS; TROUT ONCORHYNCHUS-MYKISS; CARP CYPRINUS-CARPIO; MALE RAINBOW-TROUT; MALE BROWN TROUT; COMMON CARP; GLUCOCORTICOID RECEPTORS; GAIRDNERI RICHARDSON; PLASMA-CORTISOL;
Keywords:
stress; chub; rainbow trout; cortisol; glucose; lactate; 11-ketotestosterone; 17 beta-estradiol; cortisol receptor; glucocorticoid resistance; salmonid; cyprinid; Oncorhyncus mykiss; Leuciscus cephalus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Pottinger, TG NERC, Ctr Ecol & Hydrol, Windermere Lab, Ferry House, Ambleside LA22 0LP, Cumbria, England NERC Ferry House Ambleside Cumbria England LA22 0LP England
Citazione:
T.G. Pottinger et al., "High blood cortisol levels and low cortisol receptor affinity: Is the chub, Leuciscus cephalus, a cortisol-resistant teleost?", GEN C ENDOC, 120(1), 2000, pp. 108-117

Abstract

In contrast to the relatively minor intra- and interspecies differences inblood cortisol levels reported for salmonid species, there is a more pronounced distinction between cortisol levels among the Salmonidae and the Cyprinidae, with both basal and stress-induced cortisol levels markedly higher in the latter. This study shows that in the chub, Leuciscus cephalus, a widely distributed European cyprinid, mean blood cortisol levels during stress(1500 ng mL(-1)) exceeded those reported for most other species of fish and, even in unstressed chub, cortisol levels (50-100 ng mL(-1)) were within the range known to cause immunosuppression, growth retardation, and reproductive dysfunction in salmonid fish. The chub appears to be atypical only with respect to plasma cortisol levels; the levels of plasma glucose and plasma lactate in unstressed and stressed chub are similar to those reported for other species. Plasma levels of 11-ketotestosterone in males and: 17 beta-estradiol in females are lower than those reported for salmonids but similar to those reported for other cyprinid species and display clear stress-induced reduction. Comparative analysis of the binding characteristics of the trout and chub gill cortisol receptor revealed that the total number of binding sites in gill tissue for each species was similar (B-max; similar to50-100 fmol mg(-1) protein). However, the affinity of the binding site forcortisol displayed an eightfold difference between the species (rainbow trout: K-d similar to6 nM; chub: K-d similar to 50 nM). Therefore, the potentially adverse effects of high circulating levels of cortisol found both at rest and under conditions of stress in chub may be offset by the lower affinity of the cortisol receptor, rather than the abundance of target-tissue receptor sites. This strategy is similar to that reported for some glucocorticoid-resistant rodents and New World primates. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:09:04