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Titolo:
Monoamine oxidase inhibitors reduce conditioned fear stress-induced freezing behavior in rats
Autore:
Maki, Y; Inoue, T; Izumi, T; Muraki, I; Ito, K; Kitaichi, Y; Li, XB; Koyama, T;
Indirizzi:
Hokkaido Univ, Grad Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 406, anno: 2000,
pagine: 411 - 418
SICI:
0014-2999(20001020)406:3<411:MOIRCF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOCIAL PHOBIA; SEROTONIN; MAO; METHAMPHETAMINE; BROFAROMINE; MOCLOBEMIDE; PHENELZINE; RELEASE; 5-HYDROXYTRYPTAMINE; NEUROTRANSMISSION;
Keywords:
anxiety; conditioned fear stress; freezing behavior; monoamine oxidase inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Hokkaido Univ, Grad Sch Med, Dept Psychiat, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ North 15,West 7 SapporoHokkaido Japan 0608638 apan
Citazione:
Y. Maki et al., "Monoamine oxidase inhibitors reduce conditioned fear stress-induced freezing behavior in rats", EUR J PHARM, 406(3), 2000, pp. 411-418

Abstract

The present study examined the acute anxiolytic effects of monoamine oxidase inhibitors on freezing behavior, a putative index of anxiety induced by conditioned fear stress. The selective serotonin 1A receptor agonist tandospirone (0.1-10 mg/kg) inhibited freezing dose dependently. The irreversible, non-selective monoamine oxidase inhibitors tranylcypromine (3 and 15 mg/kg) and phenelzine (30 and 80 mg/kg) reduced freezing significantly. Clorgyline (10 mg/kg, irreversible selective monoamine oxidase A inhibitor), N-(2-aminoethyl)-5-(m-fluorophenyl)-4-thiazole carboxamide (Ro 41-1049) (30 mg/kg, reversible selective monoamine oxidase A inhibitor), selegiline (3 mg/kg, irreversible selective monoamine oxidase B inhibitor) and lazabemide (10 mg/kg, reversible selective monoamine oxidase B inhibitor) had no effect onfreezing behavior. However, combined administration of clorgyline (10 mg/kg) and selegiline (3 mg/kg) reduced freezing significantly, as well as combined administration of clorgyline (10 mg/kg) and lazabemide (10 mg/kg), Ro 41-1049 (30 mg/kg) and selegiline (3 mg/kg), or Ro 41-1049 (30 mg/kg) and lazabemide (10 mg/kg). These effects of monoamine oxidase inhibitors on freezing were not due to non-specific motor effects. These results suggest thatacute inhibition of both monoamine oxidase A and B reduced anxiety or fear, while inhibition of monoamine oxidase A or B alone failed to reduce anxiety or fear. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:06:26