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Titolo:
Membrane transporters
Autore:
Lee, VHL;
Indirizzi:
Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 eut Sci, Los Angeles, CA 90089 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
, volume: 11, anno: 2000, supplemento:, 2
pagine: S41 - S50
SICI:
0928-0987(200010)11:<S41:MT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRUSH-BORDER MEMBRANE; CARRIER-MEDIATED TRANSPORT; DEPENDENT NUCLEOSIDE TRANSPORT; INTESTINAL EPITHELIAL-CELLS; ORGANIC CATION TRANSPORTER; HUMAN DOPAMINE TRANSPORTER; BETA-LACTAM ANTIBIOTICS; IN-VITRO EVALUATION; PROTEIN-KINASE-C; PIGMENTED RABBIT CONJUNCTIVA;
Keywords:
PepT1; substrate specificity; trafficking; excipient; drug-drug interaction; drug-nutrient interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, VHL Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, 1985 Zonal Ave,PSC708, LosAngeles, CA 90089 USA Univ So Calif 1985 Zonal Ave,PSC 708 Los Angeles CA USA 90089 USA
Citazione:
V.H.L. Lee, "Membrane transporters", EUR J PH SC, 11, 2000, pp. S41-S50

Abstract

Carrier-mediated drug transport is relatively unexplored in comparison with passive transcellular and paracellular drug transport. Yet, there is a host of transporter proteins that can be targeted for improving epithelial drug absorption. Generally, these are transport mechanisms for amino acids, dipeptides, monosaccharides, monocarboxylic acids, organic cations, phosphates, nucleosides, and water-soluble vitamins. Among them, the dipeptide transporter mechanism has received the most attention. Dipeptide transporters are H+-coupled, energy-dependent transporters that are known to play an essential role in the oral absorption of beta -lactam antibiotics, an,angiotensin-converting enzyme (ACE) inhibitors, renin inhibitors, and an anti-tumor drug, bestatin. Moreover, several investigators have demonstrated the utility of the dipeptide transporter as a platform for improving the oral bioavailability of drugs such as zidovudine and acyclovir through dipeptide prodrug derivatization. Thus far, at least four proton-coupled peptide transporters have been cloned. The first one cloned was PepT1 from the rabbit small intestine. The focus of this presentation will be structure-function, intracellular trafficking, and regulation of PepT1. Disease, dietary, and possible excipient influences on PepT1 function will also be discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:44:44