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Titolo:
Measurement of extrastriatal D-2-like receptor binding with [C-11]FLB 457 - a test-retest analysis
Autore:
Vilkman, H; Kajander, J; Nagren, K; Oikonen, V; Syvalahti, E; Hietala, J;
Indirizzi:
Univ Turku, Dept Pharmacol & Clin Pharmacol, FIN-20520 Turku, Finland UnivTurku Turku Finland FIN-20520 n Pharmacol, FIN-20520 Turku, Finland Turku Univ, Cent Hosp, Radiopharmaceut Chem Lab, Turku PET Ctr, FIN-20521 Turku, Finland Turku Univ Turku Finland FIN-20521 rku PET Ctr, FIN-20521 Turku, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 27, anno: 2000,
pagine: 1666 - 1673
SICI:
0340-6997(200011)27:11<1666:MOEDRB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; AUTORADIOGRAPHIC LOCALIZATION; D-2-DOPAMINE RECEPTORS; GRAPHICAL ANALYSIS; I-125 EPIDEPRIDE; C-11 RACLOPRIDE; HUMAN FOREBRAIN; PET; RADIOLIGAND; MODEL;
Keywords:
dopamine; extrastriatal dopamine D-2 receptor; positron emission tomography; [C-11]FLB-457; reproducibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Vilkman, H Univ Turku, Dept Pharmacol & Clin Pharmacol, Kiinamyllynkatu 10, FIN-20520Turku, Finland Univ Turku Kiinamyllynkatu 10 Turku Finland FIN-20520 Finland
Citazione:
H. Vilkman et al., "Measurement of extrastriatal D-2-like receptor binding with [C-11]FLB 457 - a test-retest analysis", EUR J NUCL, 27(11), 2000, pp. 1666-1673

Abstract

[C-11]FLB 457 is a radioligand for positron emission tomography (PET) thatpossesses high affinity to D-2/D-3 receptors. It has been suggested to be useful for quantification of low-density dopamine D-2 receptor populations,e.g. in cortical and limbic brain areas, We explored the reproducibility of five methods for measuring extrastriatal D-2-like receptor binding potential with [C-11]FLB 457. Seven healthy male volunteers were examined twice with [C-11]FLB 457 thigh specific radioactivity) on the same day, at least 3h apart. Four brain areas, frontal cortex, nucleus thalamus, temporal cortex and cerebellar cortex, were examined. Binding potentials (BPs) were derived from ii) a target to cerebellum distribution volume ratio, (2/3) two reversible reference tissue compartment models and (4) a transient equilibrium approach. For comparison, BP values were also calculated with the standard three-compartment kinetic model that does not assume a receptor-free reference region. The use of the standard three-compartment model did not result in reproducible BP estimates, The distribution volume (DV) ratio, reference tissue compartment models and the transient equilibrium method all had good to excellent intraclass correlation coefficients (ICCs) in the studied brain areas ranging from 0.56 to 0.93. Absolute variability was also relatively low, ranging from 5.3% to 10.4%. There were no marked differences in the ICC or absolute and relative variability between the four methods based on a reference tissue (cerebellum). In addition, we did not observe systematic differences in the BP between the first and the second scan. These dataindicate that the reproducibility of the DV ratio, reference tissue modelsand the transient equilibrium method is good or excellent. However, each of these methods includes assumptions affecting their validity. Thus, the choice of method will be critically dependent on the purpose of the study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 03:53:51