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Titolo:
Evaluation of chemotherapy response in primary bone tumors with F-18FDG positron emission tomography compared with histologically assessed tumor necrosis
Autore:
Franzius, C; Sciuk, J; Brinkschmidt, C; Jurgens, H; Schober, O;
Indirizzi:
Univ Munster Hosp, Dept Nucl Med, Munster, Germany Univ Munster Hosp Munster Germany Hosp, Dept Nucl Med, Munster, Germany Univ Munster Hosp, Gerhard Domagk Inst Pathol, Munster, Germany Univ Munster Hosp Munster Germany Domagk Inst Pathol, Munster, Germany Univ Munster Hosp, Dept Pediat, Munster, Germany Univ Munster Hosp Munster Germany r Hosp, Dept Pediat, Munster, Germany Univ Munster Hosp, Dept Pediat Hematol & Oncol, Munster, Germany Univ Munster Hosp Munster Germany iat Hematol & Oncol, Munster, Germany
Titolo Testata:
CLINICAL NUCLEAR MEDICINE
fascicolo: 11, volume: 25, anno: 2000,
pagine: 874 - 881
SICI:
0363-9762(200011)25:11<874:EOCRIP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOADJUVANT THERAPY RESPONSE; SOFT-TISSUE SARCOMA; OSTEO-SARCOMA; PREOPERATIVE CHEMOTHERAPY; FLUORINE-18-FDG PET; EWING SARCOMA; FOLLOW-UP; FDG-PET; FLUORODEOXYGLUCOSE; OSTEOSARCOMA;
Keywords:
bone scintigraphy; fluorodeoxyglucose positron emission tomography; primary malignant bone tumors; response to chemotherapy; tumor necrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Franzius, C Univ Munster, Nukl Med Klin & Poliklin, Albert Schweitzer Str 33, D-48149 Munster, Germany Univ Munster Albert Schweitzer Str 33 MunsterGermany D-48149
Citazione:
C. Franzius et al., "Evaluation of chemotherapy response in primary bone tumors with F-18FDG positron emission tomography compared with histologically assessed tumor necrosis", CLIN NUCL M, 25(11), 2000, pp. 874-881

Abstract

Purpose: The purpose of this study was to evaluate the potential of positron emission tomography using F-18-fluoro-2-deoxy-D-glucose (FDG PET) to assess the chemotherapy response of primary osseous tumors compared with the degree of necrosis determined histologically. Patients and Methods: Seventeen patients with primary bone tumors (11 osteosarcomas, 6 Ewing's sarcomas) were examined using FDG PET and planar bone scintigraphy before neoadjuvant chemotherapy and before surgery. Tumor response was classified histologically according to Salzer-Kuntschik (grades I-III: good response; grades IV-VI: poor response). In both imaging methods, quantification was performed using tumor to nontumor ratios (T:NT). Results: Histologically, 15 patients were classified as having good responses (grade I, n = 1; grade II, n = 6; grade III, n = 8) and two as having poor responses (grades IV and V). FDG PET showed more than a 30% decrease inT:NT ratios in all patients who had good responses. However, three of these patients had increasing bone scintigraphy T:NT ratios, and another five had decreasing ratios of less than 30%. The patients with poor responses hadincreasing T:NT ratios and decreasing ratios of less than 30%, respectively, using both imaging methods. Conclusions: FDG PET seems to be a promising tool for evaluating the response of primary osseous tumors to chemotherapy. In this preliminary study, FDG PET was superior to planar bone scintigraphy.

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Documento generato il 23/01/21 alle ore 12:45:33