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Titolo:
Quantitative evaluation of the bitterness of commercial medicines using a taste sensor
Autore:
Uchida, T; Miyanaga, Y; Tanaka, H; Wada, K; Kurosaki, S; Ohki, T; Yoshida, M; Matsuyama, K;
Indirizzi:
Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 6638179 Hyogo 6638179, Japan Nippon Boehringer Ingelheim Co Ltd, Kawanishi Pharma Res Inst, Kawanishi 6630193, Japan Nippon Boehringer Ingelheim Co Ltd Kawanishi Japan 6630193 630193, Japan Aoyama Daini Hosp, Kawachinagano City 5860044, Japan Aoyama Daini Hosp Kawachinagano City Japan 5860044 o City 5860044, Japan
Titolo Testata:
CHEMICAL & PHARMACEUTICAL BULLETIN
fascicolo: 11, volume: 48, anno: 2000,
pagine: 1843 - 1845
SICI:
0009-2363(200011)48:11<1843:QEOTBO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICHANNEL;
Keywords:
taste sensor; bitterness; human gustatory sensation; quinine; sucrose; aspartame; caffeine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Uchida, T Mukogawa Womens Univ, Sch Pharmaceut Sci, 11-68 Koshien 9 Bancho, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ 11-68 Koshien 9 Bancho Nishinomiya Hyogo Japan 6638179
Citazione:
T. Uchida et al., "Quantitative evaluation of the bitterness of commercial medicines using a taste sensor", CHEM PHARM, 48(11), 2000, pp. 1843-1845

Abstract

The bitterness of 11 commercial medicines was evaluated both by a multichannel taste sensor and in human gustatory sensation tests with 15 volunteers, For basic drugs with amino groups in the molecule, such as quinine, therewas a comparatively strong relative response electric potential (mV) of channels 1 or 2, those containing negatively charged membranes and the bitterness determined by human gustatory sensation tests. The suppression of the bitterness of quinine by sucrose and aspartame could be quantified using the artificial taste sensor and the results concurred with those from gustatory sensation tests. The usefulness of the sensor was thus confirmed for this type of compound,Anionic drugs, such as diclofenac sodium or salicylic acid gave rise in a negative response electric potential in channels 5 or 6, those containing positively charged membrane, seemed to be useful information even though their tastes are being sour rather than bitter. For drugs with both an amino (cationic) group and carboxylic acid (anionic) group in the molecule, such as theophylline, caffeine, and metronidazole,the relative response electric potential (mV) of channels containing negatively charged membranes was not increased, even though bitterness was observed in human gustatory sensation tests, Therefore, a different design of membrane component is required for more general evaluation of the bitterness of various medicines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:10:57