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Titolo:
Chemiluminescence-HPLC for the assay of guanidino compounds
Autore:
Nohara, Y; Hanai, T; Kinoshita, T; Watanabe, M;
Indirizzi:
Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 armaceut Sci, Kanagawa 1990195, Japan Hlth Res Fdn, Int Inst Technol Anal, Sakyo Ku, Kyoto 606, Japan Hlth Res Fdn Kyoto Japan 606 st Technol Anal, Sakyo Ku, Kyoto 606, Japan Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan Kitasato Univ Tokyo Japan 1088641 t Sci, Minato Ku, Tokyo 1088641, Japan
Titolo Testata:
CHEMICAL & PHARMACEUTICAL BULLETIN
fascicolo: 11, volume: 48, anno: 2000,
pagine: 1841 - 1842
SICI:
0009-2363(200011)48:11<1841:CFTAOG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; POST-COLUMN DERIVATIZATION; HEMODIALYSIS; NINHYDRIN; SYSTEM;
Keywords:
guanidino compound; chemiluminescence; ninhydrin; lucigenin; HPLC; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, Y Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 ci, Kanagawa 1990195, Japan
Citazione:
Y. Nohara et al., "Chemiluminescence-HPLC for the assay of guanidino compounds", CHEM PHARM, 48(11), 2000, pp. 1841-1842

Abstract

A chemiluminescence-HPLC system for the assay of serum guanidino compoundswas established. In this study; we found that lucigenin added to the reaction mixture containing guanidino compounds and alkaline-ninhydrin reagent resulted in strong chemiluminescence. The lucigenin chemiluminescence was not derived from fluorescent derivatives of guanidino compounds or ninhydrin. The interaction of guanidino compounds and ninhydrin under alkaline conditions produced reactive oxygen species. We applied this phenomenon to the microanalysis of guanidino compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:00:17