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Titolo:
Preparation and characterization of acrylic hydrogels neutralized by basicamino acids
Autore:
Uchida, T; Toida, Y; Miyanaga, Y; Machida, K; Wada, K; Ohki, T; Matsuyama, K;
Indirizzi:
Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 6638179 Hyogo 6638179, Japan Nippon Boehringer Ingelheim Co Ltd, Kawanishi Pharma Res Inst, Kawanishi 6630193, Japan Nippon Boehringer Ingelheim Co Ltd Kawanishi Japan 6630193 630193, Japan
Titolo Testata:
CHEMICAL & PHARMACEUTICAL BULLETIN
fascicolo: 11, volume: 48, anno: 2000,
pagine: 1828 - 1830
SICI:
0009-2363(200011)48:11<1828:PACOAH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTION; RATS;
Keywords:
basic amino acid; acrylic polymer; lysine; arginine; neutralizer; salicylic acid; theophylline; bovine insulin; hydrogel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Uchida, T Mukogawa Womens Univ, Sch Pharmaceut Sci, 11-68 Koshien 9 Bancho, Nishinomiya, Hyogo 6638179, Japan Mukogawa Womens Univ 11-68 Koshien 9 Bancho Nishinomiya Hyogo Japan 6638179
Citazione:
T. Uchida et al., "Preparation and characterization of acrylic hydrogels neutralized by basicamino acids", CHEM PHARM, 48(11), 2000, pp. 1828-1830

Abstract

Basic amino acids were used as neutralizers in the gellation of Eudispert(R) as an acrylic hydrogel. Arginine and lysine successfully neutralized Eudispert, as did sodium hydroxide, and formed hydrogels. A gentle rise of pH was observed as the dosage of the base increased when arginine and lysine were used, in contrast to the sharp rise of pH observed when sodium hydroxide was used, The rank of viscosity of the prepared hydrogels was as follows:lysine>arginine>NaOH. The release rate of model drugs (salicylic acid, theophylline, and bovine Insulin) from the prepared hydrogels ranked as follows: NaOH>lysine>arginine, the sustained-release profile being observed,vith arginine, The rate of diffusion of the model drug from the hydrogel was inversely proportional to the molecular weight of the cationized neutralizer used. It is concluded that the strategy of neutralization of acidic polymersby basic amino acids has advantage with the respect to both the sustained-release characteristics of the gel and the biocompatibility of the basic amino acids themselves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:21:20