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Titolo:
Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453
Autore:
Smith, MI; Read, SJ; Chan, WN; Thompson, M; Hunter, AJ; Upton, N; Parsons, AA;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Neurosci Res, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England
Titolo Testata:
CEPHALALGIA
fascicolo: 6, volume: 20, anno: 2000,
pagine: 546 - 553
SICI:
0333-1024(200007)20:6<546:RCSDIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; NITRIC-OXIDE; RAT-BRAIN; MIGRAINE; AURA; METABOLISM; SB-204269;
Keywords:
spreading depression; migraine; cerebral vasodilatation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Parsons, AA SmithKline Beecham Pharmaceut, Dept Cardiovasc Pharmacol, 709 Swedeland Rd, King Of Prussia, PA 19406 USA SmithKline Beecham Pharmaceut 709 Swedeland Rd King Of Prussia PA USA 19406
Citazione:
M.I. Smith et al., "Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453", CEPHALALGIA, 20(6), 2000, pp. 546-553

Abstract

Transient cortical depolarization is implicated in the pathology of migraine. SE-220453 is a potent anti-convulsant which inhibits neurogenic inflammation and cortical spreading depression (SD)-evoked nitric oxide release via a novel but unknown mechanism. This study further investigates the effects of SB-220453 on generation and propagation of repetitive SD in the anaesthetized cat. Vehicle or SB-220453 1, 3 or 10 mg/kg was administered intraperitoneally 90 min prior to induction of SD in the suprasylvian gyrus (SG). Changes in d.c. potential were recorded in the SG and the adjacent marginalgyrus (MG). In vehicle-treated animals (n = 7), a brief exposure (6 min) to KCI induced a median (25-75% range) number of five (four to six) and three (two to four) depolarizations over a duration of 55 min (32-59 min) and 51 min (34-58 min) in the SG and MG, respectively. SE-220453 produced dose-related inhibition of the number of events and period of repetitive SD activity. SE-220453 also reduced SD-induced repetitive pial vasodilatation but had no effect on resting haemodynamics. However, when SD events were observed in the presence of SB-220453, it had no effect on metabolic coupling. These results show that SE-220453 produces marked inhibition of repetitive SD in the anaesthetized cat. SE-220453 may therefore have therapeutic potential in treatment of SD-like activity in migraine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:56:24