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Titolo:
Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors
Autore:
Parker, MH; Ortwine, DF; OBrien, PM; Lunney, EA; Banotai, CA; Mueller, WT; McConnell, P; Brouillette, CG;
Indirizzi:
Univ Alabama, Ctr Biophys Sci & Engn, Biomol Anal Grp, Lab Biol Calorimetry, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 alorimetry, Birmingham, AL 35294 USA Pfizer Global Res & Dev, Dept Chem, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 m, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev, Dept Mol Biol, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 l, Ann Arbor, MI 48105 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 21, volume: 10, anno: 2000,
pagine: 2427 - 2430
SICI:
0960-894X(20001106)10:21<2427:SBOAEP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-CAPACITY CHANGES; CATALYTIC DOMAIN; TITRATION CALORIMETRY; WATER-STRUCTURE; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Parker, MH Vertex Pharmaceut Inc, 130 Waverly St, Cambridge, MA 02139 USA Vertex Pharmaceut Inc 130 Waverly St Cambridge MA USA 02139 USA
Citazione:
M.H. Parker et al., "Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors", BIOORG MED, 10(21), 2000, pp. 2427-2430

Abstract

Isothermal titration calorimetry was used to analyze the binding of an enantiomeric pair of inhibitors to the stromelysin-1 catalytic domain. Differences in binding affinity are attributable to different conformational entropy penalties suffered upon binding. Two possible explanations for these differences are proposed. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:43:59