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Titolo:
Pindolol augmentation of antidepressant treatment: Recent contributions from brain imaging studies
Autore:
Martinez, D; Broft, A; Laruelle, M;
Indirizzi:
Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Dept Radiol,New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 48, anno: 2000,
pagine: 844 - 853
SICI:
0006-3223(20001015)48:8<844:PAOATR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; SEROTONIN REUPTAKE INHIBITORS; POSTSYNAPTIC 5-HT1A RECEPTORS; IN-VIVO MICRODIALYSIS; LEARNED HELPLESSNESS PARADIGM; MIXED AGONIST-ANTAGONIST; FREELY-MOVING RATS; MAJOR DEPRESSION; DOUBLE-BLIND; DORSAL RAPHE;
Keywords:
serotonin; pindolol; major depression; PET; [C-11]WAY 100635;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, D Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Dept Psychiat, 1051 Riverside Dr,Box 42, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 1051 Riverside Dr,Box 42 New York NY USA 10032
Citazione:
D. Martinez et al., "Pindolol augmentation of antidepressant treatment: Recent contributions from brain imaging studies", BIOL PSYCHI, 48(8), 2000, pp. 844-853

Abstract

Preclinical studies suggest that augmentation of selective serotonin (5-HT) reuptake inhibitors by the 5-HT1A receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response, an effect largely mediated by blockade of 5-HT1A autoreceptors in the dorsal raphe nuclei. Although some controlled clinical trials suggest that pindolol might reduce latency to selective serotonin reuptake inhibitor response in acute depressive episodes, the effect is moderate and highly variable. Recentpositron emission tomography studies investigating the occupancy of 5-HT1Areceptors in humans by pindolol have shown that at the dose used most often in clinical trials the occupancy is low and variable, which might explainthe inconsistent clinical results. Positron emission tomography studies also suggest that pindolol might be more potent at blocking 5-HT1A autoreceptors than at blocking postsynaptic receptors, a property that may be useful in this pharmacologic strategy. Thus, the positron emission tomography datasupport the potential of pindolol to augment the antidepressant response of selective serotonin reuptake inhibitors, but also imply that this potential has not been fully evaluated. Here we review the clinical trials, the positron emission tomography studies, and the possible mechanisms of pindololaugmentation. It is also suggested that positron emission tomography may be used to define therapeutic dosing early on in the process of clinical evaluation of new treatment strategies. Biol Psychiatry 2000;48:844-853 (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:01:27