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Titolo:
Imaging serotonergic neurotransmission in depression: Hippocampal pathophysiology may mirror global brain alterations
Autore:
Fujita, M; Charney, DS; Innis, RB;
Indirizzi:
VA Connecticut Healthcare Syst, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Pharmacol, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Pharmacol, W Haven, CT 06516 USA NIMH, Program Mood & Anxiety Disorders, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 od & Anxiety Disorders, Bethesda, MD 20892 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 48, anno: 2000,
pagine: 801 - 812
SICI:
0006-3223(20001015)48:8<801:ISNIDH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; POSITRON-EMISSION-TOMOGRAPHY; DEXAMETHASONE SUPPRESSION TEST; 5-HT1A RECEPTOR RADIOLIGAND; MAJOR DEPRESSION; SUICIDE VICTIMS; DOUBLE-BLIND; RADIOACTIVE METABOLITES; BINDING-SITES; IN-VIVO;
Keywords:
stress; corticosteroids; pindolol; emission tomography; neurogenesis; drug effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M VA Connecticut Healthcare Syst, 116A2,950 Campbell Ave, W Haven,CT 06516 USA VA Connecticut Healthcare Syst 116A2,950 Campbell Ave W HavenCT USA 06516
Citazione:
M. Fujita et al., "Imaging serotonergic neurotransmission in depression: Hippocampal pathophysiology may mirror global brain alterations", BIOL PSYCHI, 48(8), 2000, pp. 801-812

Abstract

The recent development of [carbonyl-C-11]WAY-100635 for serotonin (5-HT)(1A) and [F-18]setoperone and [F-18]altanserin for 5-HT2A positron emission tomography receptor imaging has allowed studies of 5-HT neurotransmission indepressive disorders. The hippocampus is likely to be art important brain structure in the pathophysiology of depression because it may mediate both cognitive deficits and hypercortisolemia found in this disorder. Decreased 5-HT1A binding was reported in the medial temporal cortex, which receives dense 5-HT innervation, and also throughout neocortical regions. Because the5-HT1A antagonist pindolol may hasten antidepressant effects of selective serotonin reuptake inhibitor medications, its receptor occupancy has been measured in both presynaptic and postsynaptic sires. The results are controversial but suggest that pindolol has preferential occupancy of somatodendritic autoreceptors in the raphe. The results of 5-HT2A receptors are mixed, with one showing a significant decrease in the right orbitoinsular cortex and three not detecting a significant change, The disparate findings in patients with depression almost certainly reflect the heterogeneity of the disorder, and we highlight the utility of the hippocampus as a useful target region not only to compare depressed subjects with healthy subjects bur also to correlate findings with cognitive function and activity of the limbic-hypothalamic-pituitary axis system. Biol Psychiatry 2000;48:801-812 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 27/01/20 alle ore 07:33:13